Galangin prevents gentamicin-induced nephrotoxicity by modulating oxidative damage, inflammation and apoptosis in rats.

Autor: Abukhalil MH; Department of Medical Analysis, Princess Aisha Bint Al-Hussein Faculty of Nursing and Health Sciences, Al-Hussein Bin Talal University, Ma'an, 71111, Jordan. mabukhalil@ahu.edu.jo.; Department of Biology, College of Science, Al-Hussein Bin Talal University, Ma'an, 71111, Jordan. mabukhalil@ahu.edu.jo., Al-Alami Z; Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, 19328, Jordan., Altaie HAA; Department of Medical Laboratory Techniques, College of Medical Technology, Al-kitab University, Kirkuk, 36001, Iraq., Aladaileh SH; Department of Pharmacy Practice, College of Pharmacy, University of Hafr Al-Batin, Hafr Al- Batin, 31991, Saudi Arabia., Othman SI; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, 11671, Saudi Arabia., Althunibat OY; Department of Medical Analysis, Princess Aisha Bint Al-Hussein Faculty of Nursing and Health Sciences, Al-Hussein Bin Talal University, Ma'an, 71111, Jordan., Alfwuaires MA; Department of Biological Sciences, Faculty of Science, King Faisal University, Al-Ahsa, 31982, Saudi Arabia., Almuqati AF; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hafr Al-Batin, Hafr Al-Batin, 31991, Saudi Arabia., Alsuwayt B; Department of Pharmacy Practice, College of Pharmacy, University of Hafr Al-Batin, Hafr Al- Batin, 31991, Saudi Arabia., Rudayni HA; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh, 11623, Saudi Arabia., Allam AA; Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt., Mahmoud AM; Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt. ayman.mahmoud@science.bsu.edu.eg.
Jazyk: angličtina
Zdroj: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Oct 02. Date of Electronic Publication: 2024 Oct 02.
DOI: 10.1007/s00210-024-03449-1
Abstrakt: The well-known antibiotic gentamicin (GEN) works well against a variety of pathogenic bacteria, nevertheless its therapeutic use might be limited by the possibility of nephrotoxicity. The naturally occurring flavonoid galangin (GAL) has several interesting anti-inflammatory and antioxidant properties. The present study evaluated the nephroprotective effect of GAL on GEN-induced renal injury. Rats received GAL for 14 days and GEN from day 8 to day 14. There was a significant increase in serum urea and creatinine along with several histopathological changes in the kidney following GEN administration. GEN-treated rats also showed increased levels of kidney MDA and NO, and decreased GSH content and activities of antioxidant enzymes. Rats received GEN also demonstrated increased NF-κB p65, iNOS, TNF-α, IL-1β and IL-6 levels in the kidney. GAL remarkably prevented tissue injury, attenuated MDA and NO levels, improved antioxidants, and decreased levels of inflammatory mediators in the kidney of GEN-treated rats. Furthermore, GEN-administrated rats exhibited increased Bax and caspase-3 with concomitant decline in Bcl-2 levels in the kidney, an effect that GAL attenuated. In conclusion, GAL prevents GEN-induced nephrotoxicity by attenuating oxidative stress, inflammation, and apoptosis and augmenting antioxidant defense, suggesting its therapeutic potential against drug nephrotoxicity.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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