Lenticulostriatal Ischemia Shows Relevant SSTR Expression on PET/CT Imaging Using the Novel SSTR-Targeting Peptide 18 F-SiTATE.

Autor:	Kunte SC; From the Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany., Unterrainer LM, Kunz WG; Department of Radiology, University Hospital, LMU Munich, Munich, Germany., Winkelmann M; Department of Radiology, University Hospital, LMU Munich, Munich, Germany., Lindner S; From the Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany., Jurkschat K; Fakultät für Chemie und Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany., Wängler C; Biomedical Chemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany., Wängler B; Molecular Imaging and Radiochemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany., Schirrmacher R; Department of Oncology, Division of Oncological Imaging, University of Alberta, Edmonton, Alberta, Canada., Bartenstein P; From the Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany., Belka C; Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany., Schichor C; Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany., Albert NL; From the Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany., Unterrainer M
Jazyk:	angličtina
Zdroj:	Clinical nuclear medicine [Clin Nucl Med] 2024 Dec 01; Vol. 49 (12), pp. e689-e690. Date of Electronic Publication: 2024 Oct 02.
DOI:	10.1097/RLU.0000000000005482
Abstrakt:	Abstract: A 64-year-old woman with meningioma presented with left-sided lenticulostriatal ischemia following craniotomy and debulking of a sphenoid wing meningioma. For subsequent radiotherapy planning, an SSTR-targeted PET/CT using the novel ligand 18 F-SiTATE was performed 2.5 months thereafter. The meningioma remnants showed transosseous, intrasellar, and perivascular extension around the internal carotid artery with strong SSTR expression. Moreover, there was focal 18 F-SiTATE uptake in the left caudate and corresponding contrast enhancement due to postischemic blood-brain barrier disruption and reactive SSTR expression. Therefore, increased cortical or subcortical SSTR PET signal may be related to ischemic changes even in the subacute stage after initial stroke. Competing Interests: Conflicts of interest and sources of funding: none declared. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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