Chronobiological Spatial Clusters of Cortical Regions in the Human Brain.

Autor:	Arya R; Division of Neurology, Comprehensive Epilepsy Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A.; Department of Computer Science, University of Cincinnati, Cincinnati, Ohio, U.S.A., Petito GT; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A., Housekeeper J; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A., Buroker J; Division of Neurology, Comprehensive Epilepsy Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A., Scholle C; Division of Neurology, Comprehensive Epilepsy Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A., Ervin B; Division of Neurology, Comprehensive Epilepsy Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A., Frink C; Division of Neurology, Comprehensive Epilepsy Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A., Horn PS; Division of Neurology, Comprehensive Epilepsy Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A., Liu W; Division of Neurology, Comprehensive Epilepsy Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A.; Division of Pulmonology, Center for Sleep Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A., Ruben M; Division of Human Genetics, Circadian Biology Lab, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A., Smith DF; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A.; Division of Pulmonology, Center for Sleep Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A.; Division of Otolaryngology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A.; and., Skoch J; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A.; Division of Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A., Mangano FT; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A.; Division of Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A., Greiner HM; Division of Neurology, Comprehensive Epilepsy Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A., Holland KD; Division of Neurology, Comprehensive Epilepsy Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A.
Jazyk:	angličtina
Zdroj:	Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society [J Clin Neurophysiol] 2024 Oct 02. Date of Electronic Publication: 2024 Oct 02.
DOI:	10.1097/WNP.0000000000001119
Abstrakt:	Purpose: We demonstrate that different regions of the cerebral cortex have different diurnal rhythms of spontaneously occurring high-frequency oscillations (HFOs). Methods: High-frequency oscillations were assessed with standard-of-care stereotactic electroencephalography in patients with drug-resistant epilepsy. To ensure generalizability of our findings beyond patients with drug-resistant epilepsy, we excluded stereotactic electroencephalography electrode contacts lying within seizure-onset zones, epileptogenic lesions, having frequent epileptiform activity, and excessive artifact. For each patient, we evaluated twenty-four 5-minute stereotactic electroencephalography epochs, sampled hourly throughout the day, and obtained the HFO rate (number of HFOs/minute) in every stereotactic electroencephalography channel. We analyzed diurnal rhythms of the HFO rates with the cosinor model and clustered neuroanatomic parcels in a standard brain space based on similarity of their cosinor parameters. Finally, we compared overlap among resting-state networks, described in the neuroimaging literature, and chronobiological spatial clusters discovered by us. Results: We found five clusters that localized predominantly or exclusively to the left perisylvian, left perirolandic and left temporal, right perisylvian and right parietal, right frontal, and right insular-opercular cortices, respectively. These clusters were characterized by similarity of the HFO rates according to the time of the day. Also, these chronobiological spatial clusters preferentially overlapped with specific resting-state networks, particularly default mode network (clusters 1 and 3), frontoparietal network (cluster 1), visual network (cluster 1), and mesial temporal network (cluster 2). Conclusions: This is probably the first human study to report clusters of cortical regions with similar diurnal rhythms of electrographic activity. Overlap with resting-state networks attests to their functional significance and has implications for understanding cognitive functions and epilepsy-related mortality. Competing Interests: The authors have no funding or conflicts of interest to disclose. (Copyright © 2024 by the American Clinical Neurophysiology Society.)
Databáze:	MEDLINE
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