Physiological regulation of oral saliva ion composition and flow rate are not coupled in healthy humans-Partial revision of our current knowledge required.

Autor: Schwerdt G; Julius-Bernstein-Institute of Physiology, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Straße 6, 06112, Halle (Saale), Germany., Schulz MC; Julius-Bernstein-Institute of Physiology, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Straße 6, 06112, Halle (Saale), Germany., Kopf M; Julius-Bernstein-Institute of Physiology, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Straße 6, 06112, Halle (Saale), Germany., Mildenberger S; Julius-Bernstein-Institute of Physiology, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Straße 6, 06112, Halle (Saale), Germany., Reime S; Julius-Bernstein-Institute of Physiology, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Straße 6, 06112, Halle (Saale), Germany., Gekle M; Julius-Bernstein-Institute of Physiology, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Straße 6, 06112, Halle (Saale), Germany. michael.gekle@medizin.uni-halle.de.
Jazyk: angličtina
Zdroj: Pflugers Archiv : European journal of physiology [Pflugers Arch] 2024 Oct 02. Date of Electronic Publication: 2024 Oct 02.
DOI: 10.1007/s00424-024-03025-9
Abstrakt: Appropriate composition of oral saliva is essential for a healthy milieu that protects mucosa and teeth. Only few studies, with small sample numbers, investigated physiological saliva ion composition in humans. We determined saliva ion composition in a sufficiently large cohort of healthy adults and analyzed the effect of physiological stimulation. We collected saliva from 102 adults under non-stimulated and physiologically stimulated conditions (chewing). Individual flow rates, pH, osmolality, Na + , K + , Cl - , and HCO 3 - concentrations under both conditions as well as the individual changes due to stimulation (Δvalues) were determined. Non-stimulated saliva was hypoosmolal and acidic. Na + , Cl - , and HCO 3 - concentrations remained well below physiological plasma values, whereas K + concentrations exceeded plasma values more than twofold. Stimulation resulted in a doubling of flow rates and substantial increases in pH, HCO 3 - , and Na + concentrations. Overall, stimulation did not considerably affect osmolality nor K + or Cl - concentrations of saliva. An in-depth analysis of stimulation effects, using individual Δvalues, showed no correlation of Δflow rate with Δion concentrations, indicating independent regulation of acinar volume and ductal ion transport. Stimulation-induced Δ[Na + ] correlated with Δ[HCO 3 - ] and Δ[Cl - ] but not with Δ[K + ], indicating common regulation of ductal Na + , Cl - , and HCO 3 - transport. We present a robust data set of human oral saliva ion composition in healthy adults and functional insights into physiological stimulation. Our data show (i) that flow-dependence exists for Na + and HCO 3 - but not for K + and Cl - concentrations, (ii) osmolality is flow-independent, (iii) regulation of Na + , Cl - , and HCO 3 - transport is coupled, (iv) regulation of flow rate and ion concentrations are independent and (v) spatially separated between acini and ducts, respectively.
(© 2024. The Author(s).)
Databáze: MEDLINE
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