Minimal mathematical model for glycation of albumin.

Autor: Stickle DF; Jefferson University Hospital, Philadelphia, PA, USA. Electronic address: douglas.stickle@jefferson.edu., DiNatale GJ; Jefferson University Hospital, Philadelphia, PA, USA., Molinaro R; Siemens Healthcare Diagnostics, Inc., Tarrytown, NY, USA.
Jazyk: angličtina
Zdroj: Clinical biochemistry [Clin Biochem] 2024 Dec; Vol. 133-134, pp. 110830. Date of Electronic Publication: 2024 Sep 29.
DOI: 10.1016/j.clinbiochem.2024.110830
Abstrakt: Background: Glycated albumin (GA) is often described as a reflection of glucose exposure over the past 2-4 weeks. We examined the scale of the operative interval for changes in %GA from the perspective of a theoretical model for GA formation, by simulating the time course of changes in %GA after changes in glucose.
Methods: Probability of survival of albumin (A) was according to first-order elimination based on t 1/2 of 17 days. Probability of formation of GA from A per unit time was proportional to glucose (G) and a glycation rate constant, k, deduced from reference values for %GA vs. G. We then simulated the kinetics of changes in %GA for conditions in which a prior steady-state (constant G) was followed by a step change in G.
Results: The glycation rate constant k was 9.79e-4/d/(mmol/L). We simulated changes in %GA for two scenarios involving step changes in G at time = 0: A. from 10 mmol/L to 15 mmol/L (%GA ultimately moves from 19.3% to 26.4%); B. from 15 mmol/L to 10 mmol/L (%GA ultimately moves from 26.4% to 19.3%). For both scenarios, the fractional transition of %GA between respective starting points and ultimate endpoints was after 30 days approximately 80% of the ultimate full transition.
Conclusions: Model-based calculations support the description of %GA as a reflection of G over the past 4-6 weeks, longer than the period of 2-4 weeks that is commonly cited.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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