Minimally Invasive Assessment of Peripheral Residual Disease During Maintenance or Observation in Transplant-Eligible Patients With Multiple Myeloma.

Autor: Lasa M; Cancer Center Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada, Instituto de Investigacion Sanitaria de Navarra, CIBER-ONC CB16/12/00369 and CB16/12/00489, Pamplona, Spain., Notarfranchi L; Cancer Center Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada, Instituto de Investigacion Sanitaria de Navarra, CIBER-ONC CB16/12/00369 and CB16/12/00489, Pamplona, Spain.; Department of Medicine and Surgery, University of Parma, Parma, Italy., Agullo C; Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, University of Salamanca, CIBER-ONC CB16/12/00233, Salamanca, Spain., Gonzalez C; Cancer Center Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada, Instituto de Investigacion Sanitaria de Navarra, CIBER-ONC CB16/12/00369 and CB16/12/00489, Pamplona, Spain., Castro S; Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, University of Salamanca, CIBER-ONC CB16/12/00233, Salamanca, Spain., Perez JJ; Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, University of Salamanca, CIBER-ONC CB16/12/00233, Salamanca, Spain., Burgos L; Cancer Center Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada, Instituto de Investigacion Sanitaria de Navarra, CIBER-ONC CB16/12/00369 and CB16/12/00489, Pamplona, Spain., Guerrero C; Cancer Center Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada, Instituto de Investigacion Sanitaria de Navarra, CIBER-ONC CB16/12/00369 and CB16/12/00489, Pamplona, Spain., Calasanz MJ; Cancer Center Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada, Instituto de Investigacion Sanitaria de Navarra, CIBER-ONC CB16/12/00369 and CB16/12/00489, Pamplona, Spain., Flores-Montero J; Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, University of Salamanca, CIBER-ONC CB16/12/00233, Salamanca, Spain., Oriol A; Institut Català d'Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Barcelona, Spain., Bargay J; Hospital Universitario Son Llàtzer, IdIsBa, Palma de Mallorca, Spain., Rios R; Hospital Virgen de las Nieves, Granada, Spain., Cabañas V; Hospital Virgen de la Arrixaca, Murcia, Spain., Cabrera C; Hospital San Pedro de Alcántara, Cáceres, Spain., Martinez-Martinez R; Hospital Universitario San Carlos, Madrid, Spain., Encinas C; Hospital General Universitario Gregorio Marañón, IiSGM, Madrid, Spain., De Arriba F; Hospital Morales Meseguer, IMIB-Arrixaca, Universidad de Murcia, Murcia, Spain., Hernandez MT; Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain., Palomera L; Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain., Orfao A; Department of Medicine and Cytometry Service, Cancer Research Center (IBMCC, USAL-CSIC), University of Salamanca, CIBER-ONC CB16/12/00400, Salamanca, Spain., Martinez-Lopez J; Hospital Universitario 12 de Octubre, University Complutense, CIBER-ONC CB16/12/00369, CNIO, Madrid, Spain., Mateos MV; Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, University of Salamanca, CIBER-ONC CB16/12/00233, Salamanca, Spain., San-Miguel J; Cancer Center Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada, Instituto de Investigacion Sanitaria de Navarra, CIBER-ONC CB16/12/00369 and CB16/12/00489, Pamplona, Spain., Lahuerta JJ; Hospital Universitario 12 de Octubre, University Complutense, CIBER-ONC CB16/12/00369, CNIO, Madrid, Spain., Rosiñol L; Amyloidosis and Multiple Myeloma Unit, Department of Hematology, IDIBAPS, Hospital Clinic, Barcelona, Spain., Blade J; Amyloidosis and Multiple Myeloma Unit, Department of Hematology, IDIBAPS, Hospital Clinic, Barcelona, Spain., Cedena MT; Hospital Universitario 12 de Octubre, University Complutense, CIBER-ONC CB16/12/00369, CNIO, Madrid, Spain., Puig N; Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, University of Salamanca, CIBER-ONC CB16/12/00233, Salamanca, Spain., Paiva B; Cancer Center Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada, Instituto de Investigacion Sanitaria de Navarra, CIBER-ONC CB16/12/00369 and CB16/12/00489, Pamplona, Spain.
Jazyk: angličtina
Zdroj: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2024 Oct 01, pp. JCO2400635. Date of Electronic Publication: 2024 Oct 01.
DOI: 10.1200/JCO.24.00635
Abstrakt: Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. In multiple myeloma (MM), measurable residual disease (MRD) is assessed in bone marrow (BM). However, less invasive evaluation of peripheral residual disease (PRD) in blood could be advantageous and less cumbersome. We investigated the prognostic value of PRD monitoring after 24 cycles of maintenance in 138 transplant-eligible patients with MM enrolled in the GEM2012MENOS65/GEM2014MAIN clinical trials. PRD was assessed using next-generation flow (NGF) and mass spectrometry (MS). Positive PRD by NGF in 16/138 (11.5%) patients was associated with a 13-fold increased risk of progression and/or death; median progression-free survival (PFS) and overall survival (OS) were 2.5 and 47 months, respectively. Considering patients' MRD status in BM as the reference, PRD detection using NGF showed positive and negative predictive values of 100% and 73%, respectively. Presence of PRD helped identifying patients at risk of imminent progression among those with positive MRD in BM. Patients with undetectable PRD according to both NGF and MS showed 2-year PFS and OS rates of 97% and 100%, respectively. In multivariate analyses including the Revised International Staging System and the complete remission status, only MRD in BM and PRD by NGF showed independent prognostic value for PFS. This study supports the use of less invasive PRD monitoring during maintenance or observation in transplant-eligible patients with MM.
Databáze: MEDLINE