The Role of Subcutaneous Furosemide in Heart Failure Management: A Systematic Review.

Autor: Widiarti W; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia., Saputra PBT; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga - Dr.Soetomo General Academic Hospital, Surabaya, Indonesia.; Cardiovascular Research and Innovation Center, Universitas Airlangga, Surabaya, Indonesia., Ariyanto MV; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia., Savitri CG; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga - Dr.Soetomo General Academic Hospital, Surabaya, Indonesia.; Cardiovascular Research and Innovation Center, Universitas Airlangga, Surabaya, Indonesia., Multazam CECZ; National Heart and Lung Institute, Imperial College London, London, UK., Putranto JNE; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga - Dr.Soetomo General Academic Hospital, Surabaya, Indonesia. j.nugroho.eko@fk.unair.ac.id., Alkaff FF; Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands. firasfarisialkaff@fk.unair.ac.id.; Division of Pharmacology and Therapy, Department of Anatomy, Histology, and Pharmacology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. firasfarisialkaff@fk.unair.ac.id.
Jazyk: angličtina
Zdroj: Current cardiology reports [Curr Cardiol Rep] 2024 Nov; Vol. 26 (11), pp. 1285-1296. Date of Electronic Publication: 2024 Oct 01.
DOI: 10.1007/s11886-024-02124-4
Abstrakt: Background: Acute decompensated heart failure (ADHF) patients with symptomatic congestion often require in-hospital admission for intravenous (IV) diuretic, impacting both patient well-being and healthcare expenses. Subcutaneous (SC) furosemide has a potential to facilitate outpatient management of ADHF patients. Thus, this study aims to assess the efficacy and safety of SC furosemide utilization, offering a potential alternative to traditional IV administration.
Methods: A systematic search was conducted until April 14 2024 across scientific databases. This review included studies comparing SC furosemide with oral and IV formulations in adult HF patients.
Results: This study analyzed 687 patients from 20 studies. The results demonstrate that SC furosemide can effectively manage symptomatic congestion in HF patients and results in significant cost reductions, symptom relief, and improved quality of life. Although further investigation into mortality rates is needed, SC furosemide demonstrates efficacy comparable to IV furosemide in diuresis and weight loss, with similar bioavailability and natriuretic effects. Adverse events are generally minor, predominantly related to skin irritation. Innovative strategies, such as developing isotonic alkaline solutions and improved infusion devices, are being explored to address these challenges.
Conclusion: SC furosemide offers a promising alternative for managing ADHF, particularly in symptomatic HF patients with volume overload. The integration of SC furosemide into routine clinical practice and future guidelines, could optimize the management of HF, reducing hospital admission and improving patient outcomes.
(© 2024. The Author(s).)
Databáze: MEDLINE
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