Psoriasis localization patterns in the Swiss Psoriasis Registry (SDNTT) over 11 years: an analysis by sex and age.

Autor: Birkenmaier I; Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland.; Faculty of Science, University of Zürich, Zurich, Switzerland., Maul LV; Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland.; Faculty of Medicine, University of Zürich, Zurich, Switzerland., Oyanguren I; Swiss4ward, Statistician and Data Analyst, Zurich, Switzerland., Sorbe C; Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Fröhlich F; Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland.; Faculty of Medicine, University of Zürich, Zurich, Switzerland., Schlapbach C; Department of Dermatology, Inselspital, University Hospital Bern, Bern, Switzerland., Heidemeyer K; Department of Dermatology, Inselspital, University Hospital Bern, Bern, Switzerland., Yawalkar N; Department of Dermatology, Inselspital, University Hospital Bern, Bern, Switzerland., Boehncke WH; Division of Dermatology and Venereology, Geneva University Hospitals, Geneva, Switzerland., Ring HC; Department of Dermatology, Zealand University Hospital, Roskilde, Denmark., Thyssen JP; Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Egeberg A; Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Micheroli R; Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Thomsen SF; Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Mainetti C; Department of Dermatology, Ente Ospedaliero Cantonale and Private Practice, Bellinzona, Switzerland., Cozzio A; Department of Dermatology, Cantonal Hospital St, Gallen, St. Gallen, Switzerland., Kündig TM; Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland.; Faculty of Medicine, University of Zürich, Zurich, Switzerland., Levesque MP; Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland.; Faculty of Medicine, University of Zürich, Zurich, Switzerland., Navarini A; Department of Dermatology, University Hospital Basel, Basel, Switzerland.; Department of Biomedical Research, University of Basel, 4123, Allschwil, Switzerland., Maul JT; Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland. julia-tatjana.maul@usz.ch.; Faculty of Medicine, University of Zürich, Zurich, Switzerland. julia-tatjana.maul@usz.ch.
Jazyk: angličtina
Zdroj: Archives of dermatological research [Arch Dermatol Res] 2024 Oct 01; Vol. 316 (9), pp. 654. Date of Electronic Publication: 2024 Oct 01.
DOI: 10.1007/s00403-024-03375-5
Abstrakt: Real-world data on anatomically localized psoriasis and its response to systemic therapy across different age-groups and sexes is limited. This study aimed to evaluate the severity and distribution of psoriasis over time in female and male patients receiving systemic therapies, categorized by age within the Swiss psoriasis registry (SDNTT). Patient-data was obtained over 11 years through the SDNTT. The localized Psoriasis Area and Severity Index (locPASI) of the head, trunk, upper and lower extremities was analyzed over two years following the start of systemic non-/biologic treatment. A total of 316 female and 517 male patients were analyzed. Male patients had a higher baseline locPASI for legs, trunk and arms (p < 0.001), but not for the head (p = 0.961). The locPASI for the head in younger female patients (18-40 years) had a higher score than those aged 55 + (p = 0.022) and after two years, middle aged (41-54) showed a lower score compared to younger patients (p = 0.045). Younger male patients revealed a lower score after two years of therapy in the leg- and arm-area compared to older (p = 0.018 and p = 0.048, respectively). Female patients on non-biologics had a fast initial response, converging with male patients' scores over 24 months. Over 75% locPASI reduction was observed for female head-area (81.4%), male trunk (82.7%) and legs (76.1%). Absolute locPASI ≤ 2 was achieved 3-6 months for all locations with interleukin (IL)-17, IL-12/23 and IL-23-inhibitors, except for the legs of male patients on anti-IL-17 and female patients on anti-IL-12/23 and -IL-23. After two years, male patients did not achieve a locPASI ≤ 2 for any biologic-treatment in the legs, nor for the arms on anti-TNF-α. Significant disparities in localized PASI were observed between female and male patients. The age, sex and severity of distinct localizations should be considered to optimize treatment goals.
(© 2024. The Author(s).)
Databáze: MEDLINE
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