Sticky Science: Using Complex Coacervate Adhesives for Biomedical Applications.

Autor: Kwant AN; Department of Pulmonary Diseases, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands.; Polymer Science, Zernike Institute for Advanced Materials (ZIAM), University of Groningen, Nijenborgh 3, Groningen, 9747AG, The Netherlands.; Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands.; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands., Es Sayed JS; Polymer Science, Zernike Institute for Advanced Materials (ZIAM), University of Groningen, Nijenborgh 3, Groningen, 9747AG, The Netherlands., Kamperman M; Polymer Science, Zernike Institute for Advanced Materials (ZIAM), University of Groningen, Nijenborgh 3, Groningen, 9747AG, The Netherlands., Burgess JK; Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands.; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands., Slebos DJ; Department of Pulmonary Diseases, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands.; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands., Pouwels SD; Department of Pulmonary Diseases, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands.; Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands.; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Oct 01, pp. e2402340. Date of Electronic Publication: 2024 Oct 01.
DOI: 10.1002/adhm.202402340
Abstrakt: Tissue adhesives are used for various medical applications, including wound closure, bleeding control, and bone healing. Currently available options often show weak adhesion or cause adverse effects. Recently, there has been an increasing interest in complex coacervates as medical adhesives. Complex coacervates are formed by mixing oppositely charged macromolecules that associate and undergo liquid-liquid phase separation, in which the dense bottom phase is the complex coacervate. Complex coacervates are strong and often biocompatible, and show strong underwater adhesion. The properties of the resulting materials are tunable by intrinsic factors such as polymer chemistry, molecular weight, charge density, and topology of the macromolecules, as well as extrinsic factors such as temperature, pH, and salt concentration. Therefore, complex coacervates are interesting new candidates for medical adhesives. In this review, it is described how complex coacervates form and how different factors influence their behavior. Next, an overview of recent studies on complex coacervates in the context of medical adhesives is presented. The application of complex coacervates as hemostatic or embolic agents, skin or bone repair adhesives, and soft tissue sealants is discussed. Lastly, additional possibilities for utilizing these materials in the future are discussed.
(© 2024 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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