Survival Outcomes of Total Laryngectomy: Evaluating the Intersection of Race and Social Determinants.

Autor: Oglesby KR; Department of Otolaryngology-Head & Neck Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA., Warren JD; School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., McKee E; School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Rose A; Department of Otolaryngology - Head & Neck Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA., Liddell PH; School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Jefferson GD; Department of Otolaryngology-Head & Neck Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA., Paul O; Department of Otolaryngology-Head & Neck Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA., Jackson LL; Department of Otolaryngology-Head & Neck Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA., Kane AC; Department of Otolaryngology-Head & Neck Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Jazyk: angličtina
Zdroj: The Laryngoscope [Laryngoscope] 2024 Oct 01. Date of Electronic Publication: 2024 Oct 01.
DOI: 10.1002/lary.31802
Abstrakt: Objective: Analyze joint effects of race and social determinants on survival outcomes for patients undergoing total laryngectomy for advanced or recurrent laryngeal cancer at a tertiary care institute.
Methods: Retrospective chart review of adult patients undergoing total laryngectomy for laryngeal cancer at a tertiary care center from 2013 to 2020. Extracted data included demographics, pathological staging and features, treatment modalities, and outcomes such as recurrence, fistula formation, and 2- and 5-year disease-free survival (DFS) and overall survival (OS). Area Deprivation Index (ADI) was calculated for each patient.
Results: Among 185 patients identified, 113 were Black (61.1%) and 69 were White (37.3%). No significant differences were observed between racial groups regarding age, gender, ADI, or cancer stage. There was no significant difference in 2-year DFS/OS between groups. ADI was comparable between racial groups, with the majority in the highest deprivation quintile (63.8% of Whites vs. 62.5% of Blacks). No significant differences were observed in gender, race, cancer stage, positive margins, extracapsular extension, or smoking status among ADI quintiles. We observed a significant difference in 2-year DFS stratified by ADI (p = 0.025). Stratifying by ADI and race revealed improved survival of White patients in lower quintiles but higher survival of Black patients in the highest disparity quintile (p = 0.013).
Conclusion: Overall, survival outcomes by race were comparable among laryngectomy patients, but there was a significant difference in 2-year DFS when stratified by ADI. Further research into survival outcomes related to social determinants is needed to better delineate their effects on head and neck cancer outcomes.
Level of Evidence: 3 Laryngoscope, 2024.
(© 2024 The American Laryngological, Rhinological and Otological Society, Inc.)
Databáze: MEDLINE
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