Effect of hemoglobin, albumin, lymphocyte, and platelet score on prognosis in intermediate-risk endometrial cancer according to molecular-based classification.

Autor: Ozdemir CY; Department of Gynecological Oncology, Afyonkarahisar State Hospital, Afyonkarahisar, Turkey., Cicekli N; Faculty of Medicine, Department of Gynecological Oncology, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey., Ahat B; Faculty of Medicine, Department of Gynecology and Obstetrics, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey., Marangoz B; Department of Public Health, Edirne Provincial Health Directorate, Edirne, Turkey., Konus S; Department of Public Health, Çanakkale Onsekiz Mart University, Çanakkale, Turkey., Dur R; Faculty of Medicine, Department of Gynecology and Obstetrics, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey., Arioz DT; Faculty of Medicine, Department of Gynecological Oncology, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.
Jazyk: angličtina
Zdroj: The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2024 Nov; Vol. 50 (11), pp. 2107-2112. Date of Electronic Publication: 2024 Oct 01.
DOI: 10.1111/jog.16103
Abstrakt: Objective: The aim of this study is to compare the relationship between molecular classification and HALP score in endometrial cancer (EC).
Methods: Patients who were operated with the diagnosis of EC 2014 and 2024 were included in our study. 150 patients were included in the study. We divided the patients into three groups in terms of molecular classification; group 1 was the patients with POLE mutation, group 2 was the patients with MMRd and NSMP (intermediate prognosis), and group 3 was the patients with p53 mutation. Group 2 participants were divided into two groups, a low HALP score group and a high HALP score group, according to the HALP score cut-off value.
Results: Using the value with the highest Youden's index (0.306) as a basis, it was demonstrated that the HALP score with a cut-off value of 33.735 has a sensitivity of 61.86% and a specificity of 68.75% in intermediate-risk EC. The 5-year overall survival (OS) was found to be 75.4% in intermediate-risk EC patients with low HALP scores and 91.5% in intermediate-risk EC patients with high HALP scores (p = 0.008). The 5-year progression-free survival (PFS) was found to be 86% in intermediate-risk EC patients with low HALP scores and 94.4% in intermediate-risk EC patients with high HALP scores (p = 0.089). MMR deficiency and NSMP have been considered intermediate-risk groups for endometrial cancer and are a heterogeneous group. Although the use of the HALP score to reduce this heterogeneity is successful in predicting OS, it is not sufficient for PFS.
(© 2024 Japan Society of Obstetrics and Gynecology.)
Databáze: MEDLINE
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