Exposure to aircraft noise exacerbates cardiovascular and oxidative damage in three mouse models of diabetes.

Autor:	Mihalikova D; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Stamm P; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Kvandova M; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia., Pednekar C; Institute of Genetics and Cancer, University of Edinburgh, UK., Strohm L; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Ubbens H; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Oelze M; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Kuntic M; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany., Witzler C; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Bayo Jimenez MT; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; Laboratory of RNA Archaeology, Instituto de Parasitología y Biomedicina 'López-Neyra' (CSIC), Granada, Spain., Rajlic S; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Frenis K; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.; Stem Cell Program, Boston Children's Hospital, Boston, MA, USA., Tang Q; Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Ruan Y; Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Karbach S; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany.; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Kleinert H; Department of Pharmacology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Hahad O; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany., von Kriegsheim A; Institute of Genetics and Cancer, University of Edinburgh, UK., Xia N; Department of Pharmacology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Grune T; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany., Li H; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany.; Department of Pharmacology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Kröller-Schön S; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Gericke A; Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Ruf W; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany.; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Wild PS; Preventive Cardiology and Preventive Medicine, Department of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany.; Institute of Molecular Biology (IMB), Mainz, Germany., Lurz P; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany., Münzel T; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany.; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Daiber A; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany.; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Jansen T; Department for Cardiology, Cardiology 1, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; Department of Cardiology, KVB Hospital, Königstein, Germany.
Jazyk:	angličtina
Zdroj:	European journal of preventive cardiology [Eur J Prev Cardiol] 2024 Oct 01. Date of Electronic Publication: 2024 Oct 01.
DOI:	10.1093/eurjpc/zwae320
Abstrakt:	Background: Epidemiology links noise to increased risk of metabolic diseases like diabetes and obesity. Translational studies in humans and experimental animals showed that noise causes reactive oxygen species (ROS)-mediated cardiovascular damage. The interaction between noise and diabetes, specifically potential additive adverse effects, remains to be determined. Methods and Results: C57BL/6 mice were treated with streptozotocin (i.p. injections, 50 mg/kg/d for 5d) to induce type-1 diabetes, with S961 (subcutaneous osmotic minipumps, 0.57 mg/kg/d for 7d) or fed a high-fat diet (HFD, 20 weeks) to induce type-2 diabetes. Control and diabetic mice were exposed to aircraft noise to an average sound pressure level of 72 dB(A) for 4d. While body weight was unaffected, noise reduced insulin production in all diabetes models. The oral glucose tolerance test showed only an additive aggravation by noise in the HFD model. Noise increased blood pressure and aggravated diabetes-induced aortic, mesenteric, and cerebral arterioles endothelial dysfunction. ROS formation in cerebral arterioles, the aorta, the heart, and isolated mitochondria was consistently increased by noise in all models of diabetes. Mitochondrial respiration was impaired by diabetes and noise, however without additive effects. Noise increased ROS and caused inflammation in adipose tissue in the HFD model. RNA sequencing data and alteration of gene pathway clusters also supported additive damage by noise in the setting of diabetes. Conclusion: In all three models of diabetes, aircraft noise exacerbates oxidative stress, inflammation, and endothelial dysfunction in mice with pre-existing diabetes. Thus, noise may potentiate the already increased cardiovascular risk in diabetic patients. (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
Databáze:	MEDLINE
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