Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part II - applications and preclinical advancements.

Autor:	Fathi F; REQUIMTE/LAQV, Laboratory of Bromatology and Hydrology, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Viterbo Ferreira, Portugal., Machado TOX; Laboratory of Pharmaceutical Technology, Faculty of Pharmacy of University of Porto, Viterbo Ferreira, Portugal.; Rede Nordeste de Biotecnologia-RENORBIO, University of Tiradentes, Aracaju, Sergipe, Brazil.; Department of Agroindustry, Federal Institute of Sertão Pernambucano, Campus Petrolina Zona Rural, Petrolina, PE, Brazil., de A C Kodel H; Graduation Program of Biomedicine, University of Tiradentes, Aracaju, Sergipe, Brazil., Portugal I; Department of Medicine, Cambridge Health Alliance, Cambridge, MA, USA., Ferreira IO; Laboratory of Pharmaceutical Technology, Faculty of Pharmacy of University of Porto, Viterbo Ferreira, Portugal., Zielinska A; Laboratory of Pharmaceutical Technology, Faculty of Pharmacy of University of Porto, Viterbo Ferreira, Portugal.; Institute of Natural Fibres and Medicinal Plants National Research Institute, Department of Biotechnology, Poznań, Poland., Oliveira MBPP; REQUIMTE/LAQV, Laboratory of Bromatology and Hydrology, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Viterbo Ferreira, Portugal., Souto EB; Laboratory of Pharmaceutical Technology, Faculty of Pharmacy of University of Porto, Viterbo Ferreira, Portugal.; UCD School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin, Ireland.
Jazyk:	angličtina
Zdroj:	Expert opinion on drug delivery [Expert Opin Drug Deliv] 2024 Oct; Vol. 21 (10), pp. 1491-1499. Date of Electronic Publication: 2024 Oct 04.
DOI:	10.1080/17425247.2024.2410949
Abstrakt:	Introduction: Numerous purified bioactive compounds, crude extracts, and essential oils have demonstrated potent antioxidant, antimicrobial, anti-inflammatory, and antiviral properties, particularly in vitro or in silico; however, their in vivo applications are hindered by inadequate absorption and distribution in the organism. The incorporation of these phytochemicals into solid lipid nanoparticles (SLN) or nanostructured lipid carriers (NLC) has demonstrated significant advancements and represents a viable approach to improve their bioavailability through different administration routes. Areas Covered: This review discusses the potential applications of SLN and NLC, loading bioactive compounds sourced from plants for the treatment of several diseases. An overview of the preclinical developments on the use of these lipid nanoparticles is also provided as well as the requisites to be launched on the market. Expert Opinion: Medicinal plants have gained even more value for the pharmaceutical industries and their customers, leading to many studies exploring their therapeutic potential. Several bioactives derived from plants with antiviral, anticancer, neuroprotective, antioxidant, and antiaging properties have been proposed and loaded into lipid nanoparticles. In vitro and invivo studies corroborate the added value of SLN/NLC to improve the bioavailability of several bioactives. Surface modification to increase their stability and target delivery should be considering.
Databáze:	MEDLINE
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