Predictors of recurrent restenosis after repeat drug-coated balloon therapy for drug-coated balloon restenosis in femoropopliteal lesions: Results of the RECURRENCE study.

Autor: Yanagiuchi T; Department of Cardiology, Rakuwakai Otowa Hospital, Kyoto, Japan., Fukai K; Department of Cardiovascular Medicine, Omihachiman Community Medical Center, Shiga, Japan., Sogabe K; Department of Cardiovascular Medicine, Kyoto Okamoto Memorial Hospital, Kyoto, Japan., Iwasaki Y; Cardiovascular Center, Kyoto Katsura Hospital, Kyoto, Japan., Hirano K; Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kato T; Department of Cardiology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan., Yokoi H; Department of Cardiology, Rakuwakai Otowa Hospital, Kyoto, Japan., Zen K; Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan., Matoba S; Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Jazyk: angličtina
Zdroj: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions [Catheter Cardiovasc Interv] 2024 Nov; Vol. 104 (6), pp. 1241-1250. Date of Electronic Publication: 2024 Sep 30.
DOI: 10.1002/ccd.31245
Abstrakt: Background: Despite the widespread use of drug-coated balloons (DCBs) for femoropopliteal (FP) lesions, there is still no consensus on treatment strategies for DCB restenosis. This study aimed to determine the risk factors for recurrent restenosis after repeat DCB therapy for DCB restenosis in FP lesions.
Methods: This multicenter retrospective study assessed 1176 consecutive limbs in 860 patients who successfully received initial DCB therapy for FP lesions at four cardiovascular centers between May 2018 and December 2022. Among these patients, 118 consecutive limbs of 104 patients treated via repeat DCB for primary DCB restenosis were enrolled.
Results: The Kaplan-Meier estimate of freedom from recurrent restenosis was 74.6% at 1 year. Cox proportional hazard multivariate analysis revealed that recurrent restenosis was independently associated with the time from initial DCB to primary restenosis (hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.79-0.92; p < 0.001), history of ≥2 endovascular therapies (EVTs) (HR, 3.11; 95%CI, 1.36-7.12; p = 0.007), and PACSS grade 3 or 4 (HR, 2.76; 95%CI, 1.15-6.63; p = 0.023). Furthermore, receiver operating characteristic curve analysis showed that the cutoff value of the time from initial DCB to primary restenosis to prevent recurrent restenosis was 12.6 months, with an area under the curve of 0.841 (p < 0.001).
Conclusion: Repeat DCB therapy for DCB restenosis might be an acceptable strategy, particularly for restenosis that occurred more than 12.6 months after initial DCB, given the rate of freedom from recurrent restenosis.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE