Activity of the hypothalamic neuropeptide Y increases in adult and decreases in old rats.

Autor: Eitmann S; Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti street, Pécs, 7624, Hungary., Füredi N; Research Group for Mood Disorders, Centre for Neuroscience, Medical School, University of Pécs, Pécs, Hungary.; Department of Anatomy, Medical School, University of Pécs, Pécs, Hungary., Gaszner B; Research Group for Mood Disorders, Centre for Neuroscience, Medical School, University of Pécs, Pécs, Hungary.; Department of Anatomy, Medical School, University of Pécs, Pécs, Hungary., Kormos V; Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary., Berta G; Department of Medical Biology and Central Electron Microscopic Laboratory, Medical School, University of Pécs, Pécs, Hungary., Pólai F; Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti street, Pécs, 7624, Hungary., Kovács DK; Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti street, Pécs, 7624, Hungary., Balaskó M; Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti street, Pécs, 7624, Hungary., Pétervári E; Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti street, Pécs, 7624, Hungary. erika.petervari@aok.pte.hu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Sep 30; Vol. 14 (1), pp. 22676. Date of Electronic Publication: 2024 Sep 30.
DOI: 10.1038/s41598-024-73825-7
Abstrakt: Middle-aged obesity and aging anorexia with muscle loss (sarcopenia) of old people present public health burden. These alterations may appear both in humans and rodents suggesting the role for regulatory alterations. Previously, we demonstrated that biphasic changes in the weight-reducing (catabolic) effects of neuropeptides of the hypothalamus-adipose tissue axis (e.g. leptin) may contribute to both trends. With regard to the anabolic effects of the hypothalamic neuropeptide Y (NPY) inhibited by leptin, we hypothesized non-linear age-related changes with shifts in the opposite directions. We investigated the orexigenic and hypometabolic effects of intracerebroventricularly administered NPY (hyperphagia induced by NPY injection or changes in food intake, body weight, heart rate, body temperature, locomotor activity during a 7-day NPY infusion), the immunoreactivity and gene expression of NPY in the hypothalamic arcuate nucleus of male Wistar rats of five age groups from young to old. The orexigenic/hypometabolic efficacy and the immunoreactivity of NPY increased in middle-aged animals preceding the peak of adiposity observed in aging rats, then decreased preceding anorexia and weight loss in old rats. These shifts may contribute to the development of both age-related obesity and aging anorexia, sarcopenia, and should be considered in future drug development targeting the NPY system.
(© 2024. The Author(s).)
Databáze: MEDLINE
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