Bismuth-gold nanohybrid based nano photosensitizer to combat antimicrobial resistance.

Autor: Nomani A; School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran., Nosrati H; Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran., Faraji N; School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran., Charmi J; Department of Physics, Faculty of Science, University of Zanjan, Zanjan, 45371-38791, Iran., Javani S; Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran. siamak.javani@imdea.org.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Sep 30; Vol. 14 (1), pp. 22598. Date of Electronic Publication: 2024 Sep 30.
DOI: 10.1038/s41598-024-74273-z
Abstrakt: Antimicrobial resistance (AMR) leads to a decrease in the adequacy of antimicrobial agents and an increase in the rate of adverse effects and mortality. The main objective of this project is to investigate the synergistic effect of BiAu@NCLin-T 1 and its substructures as an antimicrobial photodynamic therapy (aPDT) agent to combat microbial resistance. In addition, the effect of photothermal therapy (PTT) on some of the designed nanostructures at a temperature of 40 °C was also tested. The antimicrobial test was carried out using the growth curve method against Escherichia coli and Staphylococcus aureus. Computational methods were used to investigate the stability and entropy of oligonucleotide sequence structures. Various analyses were performed to identify the nanostructures, including Ultraviolet-visible (UV-vis) spectroscopy, Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDS) and fluorescence analysis. The BiAu@NCLin-T 1 appeared the significant aPDT impact against the gram-negative E.coli strain at two distinctive oligonucleotide concentrations (1, and 1.5 micromolar (µM)). Based on the results, the outlined nanostructures can act as a photosensitizer (PS), a photothermal treatment (PTT) agent, and an antimicrobial agent to combat resistant bacteria.
(© 2024. The Author(s).)
Databáze: MEDLINE
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