Psilocybin increases optimistic engagement over time: computational modelling of behaviour in rats.

Autor: Fisher EL; Monash Centre for Consciousness and Contemplative Studies, Monash University, Melbourne, VIC, Australia. beth.fisher@monash.edu., Smith R; Laureate Institute for Brain Research, University of Tulsa, Tulsa Oklahoma, OK, USA., Conn K; Anorexia and Feeding Disorders Laboratory, Department of Physiology, Monash University, Melbourne, VIC, Australia.; Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia., Corcoran AW; Monash Centre for Consciousness and Contemplative Studies, Monash University, Melbourne, VIC, Australia., Milton LK; Anorexia and Feeding Disorders Laboratory, Department of Physiology, Monash University, Melbourne, VIC, Australia.; Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia., Hohwy J; Monash Centre for Consciousness and Contemplative Studies, Monash University, Melbourne, VIC, Australia., Foldi CJ; Anorexia and Feeding Disorders Laboratory, Department of Physiology, Monash University, Melbourne, VIC, Australia.; Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.
Jazyk: angličtina
Zdroj: Translational psychiatry [Transl Psychiatry] 2024 Sep 30; Vol. 14 (1), pp. 394. Date of Electronic Publication: 2024 Sep 30.
DOI: 10.1038/s41398-024-03103-7
Abstrakt: Psilocybin has shown promise as a novel pharmacological intervention for treatment of depression, where post-acute effects of psilocybin treatment have been associated with increased positive mood and decreased pessimism. Although psilocybin is proving to be effective in clinical trials for treatment of psychiatric disorders, the information processing mechanisms affected by psilocybin are not well understood. Here, we fit active inference and reinforcement learning computational models to a novel two-armed bandit reversal learning task capable of capturing engagement behaviour in rats. The model revealed that after receiving psilocybin, rats achieve more rewards through increased task engagement, mediated by modification of forgetting rates and reduced loss aversion. These findings suggest that psilocybin may afford an optimism bias that arises through altered belief updating, with translational potential for clinical populations characterised by lack of optimism.
(© 2024. The Author(s).)
Databáze: MEDLINE
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