Can Peripheral Arterial Tonometry and Biomarkers Help Identify Women Who Will Have Progressively Worsening Hypertensive Disorders of Pregnancy?
| Autor: | Clifford CM; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan., Hesson AM; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan., Sangtani A; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan., Ganesh SK; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan., Langen ES; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan. |
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| Jazyk: | angličtina |
| Zdroj: | American journal of perinatology [Am J Perinatol] 2024 Sep 30. Date of Electronic Publication: 2024 Sep 30. |
| DOI: | 10.1055/a-2407-1761 |
| Abstrakt: | Objective: This study aimed to (1) evaluate whether endothelial dysfunction, as measured by peripheral arterial tonometry (PAT) indices and biomarker (soluble fms-like tyrosine kinase-1 [sFLT], brain natriuretic peptide [BNP]) levels at 34 weeks gestation, can predict progression from nonsevere to severe hypertensive disorders of pregnancy (HDPs); and (2) develop a clinical risk model for prediction of progression from nonsevere to severe HDP. Study Design: We prospectively enrolled patients with a singleton gestation carrying a nonsevere HDP diagnosis. Forty-five participants were enrolled for PAT evaluation and serum collection between 34 0/7 and 36 6/7 weeks. PAT indices (e.g., Augmentation Index normalized to a heart rate of 75 bpm [AI75]) and biomarker concentrations were assessed at enrollment. The primary outcome was progression from a nonsevere diagnosis in the late preterm period to a diagnosis of preeclampsia with severe features or superimposed preeclampsia. Statistical analyses included two-sample t -tests, Fisher's exact tests, and multivariate modeling. Results: Thirteen subjects (30%) progressed to severe disease. No significant differences in mean PAT indices between the outcome groups were found. We found a significant difference in mean sFLT values between the two groups ( p = 0.02, area under the curve [AUC] of 0.609), but not in mean BNP values. An endothelial dysfunction index (presence of fetal growth restriction, "high" AI75, and positive systolic blood pressure slope) discriminated between progression and nonprogression ( p = 0.03, AUC of 0.707). Conclusion: sFLT level was a marker of progression from nonsevere to severe HDP. Further, a novel endothelial dysfunction index discriminated between progression and nonprogression to severe disease with good performance. Key Points: · HDPs are important causes of morbidity and mortality.. · The sequelae of HDPs are not limited to pregnancy.. · Developing accurate tools to predict severe HDPs is of great clinical importance.. · Our index shows promising performance for predicting progression from nonsevere to severe HDPs.. Competing Interests: None declared. (Thieme. All rights reserved.) |
| Databáze: | MEDLINE |
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