The paradoxical impact of periodic limb movements on isolated REM sleep behavior disorder patients.

Autor: Mombelli S; Center for Advanced Research in Sleep Medicine, Centre Intégré Universitaire de Santé Et de Services Sociaux du Nord de L'Île-de-Montréal, Montréal, QC, Canada.; Department of Psychiatry and Addictology, Université de Montréal, Montréal, QC, Canada., Casoni F; Department of Clinical Neurosciences, Neurology-Sleep Disorders Center, IRCCS San Raffaele Scientific Institute, Milan, Italy., D'Este G; Department of Clinical Neurosciences, Neurology-Sleep Disorders Center, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Faculty of Psychology, Vita-Salute San Raffaele University, Milan, Italy., Leitner C; Department of Clinical Neurosciences, Neurology-Sleep Disorders Center, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Faculty of Psychology, Vita-Salute San Raffaele University, Milan, Italy., Marelli S; Department of Clinical Neurosciences, Neurology-Sleep Disorders Center, IRCCS San Raffaele Scientific Institute, Milan, Italy., Zucconi M; Department of Clinical Neurosciences, Neurology-Sleep Disorders Center, IRCCS San Raffaele Scientific Institute, Milan, Italy., Liguori C; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy.; Sleep Medicine Centre, Neurology Unit, University Hospital of Rome Tor Vergata, Rome, Italy., Ferini-Strambi L; Department of Clinical Neurosciences, Neurology-Sleep Disorders Center, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Faculty of Psychology, Vita-Salute San Raffaele University, Milan, Italy., Galbiati A; Department of Clinical Neurosciences, Neurology-Sleep Disorders Center, IRCCS San Raffaele Scientific Institute, Milan, Italy. andrea.galbiati.unisr@gmail.com.; Faculty of Psychology, Vita-Salute San Raffaele University, Milan, Italy. andrea.galbiati.unisr@gmail.com.
Jazyk: angličtina
Zdroj: Journal of neurology [J Neurol] 2024 Nov; Vol. 271 (11), pp. 7272-7281. Date of Electronic Publication: 2024 Sep 30.
DOI: 10.1007/s00415-024-12708-3
Abstrakt: Recently, the α-synuclein origin and connectome model described two types of Parkinson's disease: "brain-first" and "body-first" subtypes. We aimed to investigate the role of periodic limb movements during sleep (PLMS) in identifying these subtypes starting from a prodromal stage of α-synucleinopathies. 191 patients with isolated REM sleep behavior disorder (iRBD) underwent video-polysomnography (vPSG), questionnaires, clinical interview, and neuropsychological battery. Patients who presented PLMS index (PLMSi) > 15 were compared with patients presenting PLMSi ≤ 15 on clinical questionnaires, vPSG, and neuropsychological domains with age as a covariate. Correlations were performed between PLMSi and vPSG and neuropsychological domains in both groups of iRBD. 48.2% of patients presented PLMSi > 15. iRBD subgroup with PLMSi > 15 performed better than the iRBD subgroup with PLMSi ≤ 15 in the executive function domain. In patients with PLMSi > 15 negative correlations were observed between PLMSi and some neuropsychological domains (memory, language, and executive function). Moreover, this subgroup was older and their PLMSi was positively correlated with wake-after-sleep onset and inversely correlated with total sleep time and sleep efficiency, suggesting a detrimental effect of PLM on sleep also in this cohort. Patients with PLMSi > 15 are characterized by a more preserved cognitive status, despite a more disrupted sleep. PLMSi could be explored in longitudinal studies concerning the "brain-first" and "body-first" model.
Competing Interests: Declarations Conflicts of interest This work had no financial support. None of the authors of this manuscript had conflicts of interest. Ethical approval All the participants provided written informed consent previously approved by the local ethical committee according to the “1964 Declaration of Helsinki”.
(© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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