Relationship Between Hematologic Inflammatory Markers and Glycemic Control in Type 2 Diabetes Mellitus Patients in a Tertiary Hospital in Nigeria.

Autor:	Amaeshi L; Clinical Hematology, Internal Medicine, Lagos University Teaching Hospital, Lagos, NGA., Kalejaiye OO; Clinical Hematology, Internal Medicine, College of Medicine, University of Lagos and Lagos University Teaching Hospital, Lagos, NGA., Olopade OB; Endocrinology, Diabetes and Metabolism, Internal Medicine, Lagos University Teaching Hospital, Lagos, NGA., Kehinde M; Clinical Hematology, Internal Medicine, Lagos University Teaching Hospital, Lagos, NGA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Aug 30; Vol. 16 (8), pp. e68186. Date of Electronic Publication: 2024 Aug 30 (Print Publication: 2024).
DOI:	10.7759/cureus.68186
Abstrakt:	Introduction: Hematologic inflammatory biomarkers derived from a full blood count (FBC) are elevated in Type 2 diabetes mellitus (DM). In low- and middle-income countries like Nigeria, a FBC is an affordable and easily available test, even in rural areas. Glycated hemoglobin (HbA1c), a measure of glycemic control, has been found to correlate with hematologic inflammatory markers. In Nigeria, where health care is expensive and patients essentially pay out of pocket, a more affordable and accessible alternative to HbA1c in determining glycemic control is needed. Therefore, this study aimed to determine the relationship between Hb A1c and hematologic inflammatory biomarkers, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and mean platelet volume (MPV), in predicting glycemic control. Methods: This was a six-month study of 109 patients with Type 2 DM in a tertiary hospital in Lagos. The patients' HbA1c and FBC were measured. NLR, PLR, and MPV were derived from the FBC values. We categorized the patients based on glycemic control. Spearman correlation analysis was used to determine the relationship between HbA1c and the inflammatory biomarkers. Results: There was no significant difference in NLR, PLR, and MPV between optimal and suboptimal controlled diabetic patients. Spearman's correlation analysis showed no significant association between NLR, PLR, MPV, and HbA1c in the patients (NLR: r=0.027, P=0.680; PLR: r=-0.091, P=0.356; MPV: r=-0.032, P=0.744). Conclusion: The inflammatory markers studied had no significant relationship with HbA1c and might not help monitor glycemic control in Type 2 DM patients. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Lagos University Teaching Hospital, Health Research Ethics Committee issued approval NHREC: 19/12/2008a. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Amaeshi et al.)
Databáze:	MEDLINE
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