Analysis of the Cellular Response to Different Dental Implant Surfaces: An In vitro Study.

Autor:	Sghaireen MG; Prosthodontic Dentistry Department, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia., Alrwuili MR; Orthodontic Department, Qurayyat Specialized Dental Center, Al-Qurayyat, Saudi Arabia., Alenzi NA; Orthodontic Department, Western Riyadh Dental Complex, Riyadh, Saudi Arabia., Aljabab MA; Orthodontic Department, Qurayyat Specialized Dental Center, Al-Qurayyat, Saudi Arabia., Issrani R; Preventive Dentistry Department, College of Dentistry, Jouf University, Sakaka, Saudi Arabia., Alam MK; Preventive Dentistry Department, College of Dentistry, Jouf University, Sakaka, Saudi Arabia.; Department of Dental Research Cell, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India.; Department of Public Health, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, Bangladesh.
Jazyk:	angličtina
Zdroj:	Journal of pharmacy & bioallied sciences [J Pharm Bioallied Sci] 2024 Jul; Vol. 16 (Suppl 3), pp. S2521-S2523. Date of Electronic Publication: 2024 Jun 08.
DOI:	10.4103/jpbs.jpbs_329_24
Abstrakt:	Background: Dental implant surfaces play a crucial role in determining the success of osseointegration and long-term stability. Understanding the cellular response to various implant surfaces is essential for optimizing implant design and clinical outcomes. Materials and Methods: In this in vitro study, we investigated the cellular response to different dental implant surfaces. Titanium implants with three distinct surface treatments (polished, acid-etched, and sandblasted) were prepared. Human osteoblast-like cells were cultured on these surfaces, and cellular behaviors including adhesion, proliferation, and morphology were evaluated using standard assays and imaging techniques. Results: Our results revealed significant differences in cellular responses among the different implant surfaces. Cells exhibited higher adhesion and proliferation rates on the acid-etched and sandblasted surfaces compared to the polished surface. Furthermore, cells displayed a more spread-out morphology with well-defined filopodia and lamellipodia on the acid-etched and sandblasted surfaces, indicating enhanced cellular interaction and spreading. Conclusion: The cellular response to dental implant surfaces varies depending on surface characteristics. Acid-etched and sandblasted surfaces promote better cellular adhesion, proliferation, and spreading compared to polished surfaces. These findings underscore the importance of surface modifications in enhancing osseointegration and ultimately improving the success rates of dental implant procedures. Competing Interests: There are no conflicts of interest. (Copyright: © 2024 Journal of Pharmacy and Bioallied Sciences.)
Databáze:	MEDLINE
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