Leveraging oncology collaborative networks and biomedical informatics data resources to rapidly recruit and enroll rural residents into oncology quality of life clinical trials.

Autor:	Davis HA; Institute for Clinical & Translational Science, University of Iowa, Iowa City, IA, USA.; Carver College of Medicine IT, University of Iowa, Iowa City, IA, USA., Hoberg AA; Institute for Clinical & Translational Science, University of Iowa, Iowa City, IA, USA.; Carver College of Medicine IT, University of Iowa, Iowa City, IA, USA., Jacobus LS; Institute for Clinical & Translational Science, University of Iowa, Iowa City, IA, USA.; Vanderbilt Institute for Clinical & Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA., Nepple K; Urology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA., Seaman AT; Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA., Sorensen J; Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA., Weiner GJ; Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA., Gilbertson-White S; Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Community & Primary Care, College of Nursing, University of Iowa, Iowa City, IA, USA.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.
Jazyk:	angličtina
Zdroj:	Journal of clinical and translational science [J Clin Transl Sci] 2024 Sep 23; Vol. 8 (1), pp. e135. Date of Electronic Publication: 2024 Sep 23 (Print Publication: 2024).
DOI:	10.1017/cts.2024.576
Abstrakt:	Purpose: This study assesses the feasibility of biomedical informatics resources for efficient recruitment of rural residents with cancer to a clinical trial of a quality-of-life (QOL) mobile app. These resources have the potential to reduce costly, time-consuming, in-person recruitment methods. Methods: A cohort was identified from the electronic health record data repository and cross-referenced with patients who consented to additional research contact. Rural-urban commuting area codes were computed to identify rurality. Potential participants were emailed study details, screening questions, and an e-consent link via REDCap. Consented individuals received baseline questionnaires automatically. A sample minimum of n = 80 [ n = 40 care as usual (CAU) n = 40 mobile app intervention] was needed. Results: N = 1298 potential participants ( n = 365 CAU; n = 833 intervention) were screened for eligibility. For CAU, 68 consented, 67 completed baseline questionnaires, and 54 completed follow-up questionnaires. For intervention, 100 consented, 97 completed baseline questionnaires, and 58 completed follow-up questionnaires. The CAU/intervention reached 82.5%/122.5% of the enrollment target within 2 days. Recruitment and retention rates were 15.3% and 57.5%, respectively. The mean age was 59.5 ± 13.5 years. The sample was 65% women, 20% racial/ethnic minority, and 35% resided in rural areas. Conclusion: These results demonstrate that biomedical informatics resources can be highly effective in recruiting for cancer QOL research. Precisely identifying individuals likely to meet inclusion criteria who previously indicated interest in research participation expedited recruitment. Participants completed the consent and baseline questionnaires with zero follow-up contacts from the research team. This low-touch, repeatable process may be highly effective for multisite clinical trials research seeking to include rural residents. Competing Interests: G.J.W. is chairman of the ORIEN Steering Committee. G.J.W. and ORIEN were not involved in developing the research question, determining the research methodology, or conducting the analyses. ORIEN did not provide financial support for this study. H.A.D., A.A.H., L.S.J., K.N., A.T.S., J.S., and S.G.W. have no competing interests. (© The Author(s) 2024.)
Databáze:	MEDLINE
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