| Autor: |
Carey-Ewend K, Popkin-Hall ZR, Simkin A, Muller M, Hennelly C, He W, Moser KA, Gaither C, Niaré K, Aghakanian F, Feleke S, Brhane BG, Phanzu F, Mwandagalirwa K, Aydemir O, Sutherland CJ, Ishengoma DS, Ali IM, Ngasala B, Kalonji A, Tshefu A, Parr JB, Bailey JA, Juliano JJ, Lin JT |
| Jazyk: |
angličtina |
| Zdroj: |
BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 19. Date of Electronic Publication: 2024 Sep 19. |
| DOI: |
10.1101/2024.04.10.588912 |
| Abstrakt: |
Plasmodium ovale curtisi ( Poc) and Plasmodium ovale wallikeri ( Pow ) are relapsing malaria parasites endemic to Africa and Asia that were previously thought to represent a single species. Amid increasing detection of ovale malaria in sub-Saharan Africa, we performed a population genomic study of both species across the continent. We conducted whole-genome sequencing of 25 isolates from Central and East Africa and analyzed them alongside 20 previously published African genomes. Isolates were predominantly monoclonal (43/45), with their genetic similarity aligning with geography. Pow showed lower average nucleotide diversity (1.8×10 -4 ) across the genome compared to Poc (3.0×10 -4 ) (p < 0.0001). Signatures of selective sweeps involving the dihydrofolate reductase gene were found in both species, as were signs of balancing selection at the merozoite surface protein 1 gene. Differences in the nucleotide diversity of Poc and Pow may reflect unique demographic history, even as similar selective forces facilitate their resilience to malaria control interventions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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