Predictive filtering of sensory response via orbitofrontal top-down input.

Autor:	Tsukano H; Department of Psychiatry, University of North Carolina at Chapel Hill; Chapel Hill, 27599, USA.; Neuroscience Center, University of North Carolina at Chapel Hill; Chapel Hill, 27599, USA., Garcia MM; Department of Psychiatry, University of North Carolina at Chapel Hill; Chapel Hill, 27599, USA.; Neuroscience Center, University of North Carolina at Chapel Hill; Chapel Hill, 27599, USA., Dandu PR; Department of Psychiatry, University of North Carolina at Chapel Hill; Chapel Hill, 27599, USA.; Neuroscience Center, University of North Carolina at Chapel Hill; Chapel Hill, 27599, USA., Kato HK; Department of Psychiatry, University of North Carolina at Chapel Hill; Chapel Hill, 27599, USA.; Neuroscience Center, University of North Carolina at Chapel Hill; Chapel Hill, 27599, USA.; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill; Chapel Hill, 27599, USA.; Eaton-Peabody Laboratories, Massachusetts Eye and Ear; Boston, 02114, USA.; Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School; Boston, 02114, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 17. Date of Electronic Publication: 2024 Sep 17.
DOI:	10.1101/2024.09.17.613562
Abstrakt:	Habituation is a crucial sensory filtering mechanism whose dysregulation can lead to a continuously intense world in disorders with sensory overload. While habituation is considered to require top-down predictive signaling to suppress irrelevant inputs, the exact brain loci storing the internal predictive model and the circuit mechanisms of sensory filtering remain unclear. We found that daily neural habituation in the primary auditory cortex (A1) was reversed by inactivation of the orbitofrontal cortex (OFC). Top-down projections from the ventrolateral OFC, but not other frontal areas, carried predictive signals that grew with daily sound experience and suppressed A1 via somatostatin-expressing inhibitory neurons. Thus, prediction signals from the OFC cancel out behaviorally irrelevant anticipated stimuli by generating their "negative images" in sensory cortices. Competing Interests: Competing interests: The authors declare no competing interests.
Databáze:	MEDLINE
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