| Autor: |
Lasher AT, Liu K, Fitch M, Sun LY |
| Jazyk: |
angličtina |
| Zdroj: |
BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 22. Date of Electronic Publication: 2024 Sep 22. |
| DOI: |
10.1101/2024.09.18.613718 |
| Abstrakt: |
Prior studies show that disrupting somatotropic axis components extends laboratory mouse lifespan, but confounding effects of additional genes and hormones obscure the specific impact of growth hormone (GH) on longevity. We address this issue by using mice with a specific knockout of the GH gene, revealing that disrupting GH alone substantially increases lifespan. The longevity effects are accompanied by altered metabolic fuel utilization, directly linking GH action to aging mechanisms. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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