Head-to-head comparison of GA-68 PSMA PET/CT and multiparametric MRI findings with postoperative results in preoperative locoregional staging and localization of prostate cancer.

Autor: Dinckal M; Department of Urology, Menderes State Hospital, Izmir, Turkey., Ergun KE; Department of Urology, Ege University Faculty of Medicine, Izmir, Turkey., Kalemci MS; Department of Urology, Ege University Faculty of Medicine, Izmir, Turkey., Guler E; Department of Radiology, Ege University Faculty of Medicine, Izmir, Turkey., Tokac R; Department of Nuclear Medicine, Ege University Faculty of Medicine, Izmir, Turkey., Ordu S; Department of Urology, Ege University Faculty of Medicine, Izmir, Turkey., Ogut N; Department of Urology, Ege University Faculty of Medicine, Izmir, Turkey., Ozgul S; Department of Biostatistics, Ege University Faculty of Medicine, Izmir, Turkey., Sanli O; Department of Nuclear Medicine, Economy University Medical Point Hospital, Izmir, Turkey., Sen S; Department of Pathology, Ege University Faculty of Medicine, Izmir, Turkey., Turna B; Department of Urology, Özel Sağlık Hospital, Izmir, Turkey.
Jazyk: angličtina
Zdroj: The Prostate [Prostate] 2025 Jan; Vol. 85 (1), pp. 48-57. Date of Electronic Publication: 2024 Sep 30.
DOI: 10.1002/pros.24799
Abstrakt: Background: Accurate staging of prostate cancer (PCa) is essential for determining the appropriate treatment and predicting outcomes. This study is comparing the effectiveness of Gallium-68 Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography (Ga-68 PSMA PET/CT) and multiparametric MRI (mpMRI) in preoperative locoregional staging and localizing PCa.
Methods: A retrospective analysis was conducted on 78 patients who underwent both mpMRI and Ga-68 PSMA PET/CT scans before surgery. The imaging was reviewed by radiologists and nuclear medicine specialists and compared with the final histopathology, which was reviewed by an experienced uropathologist.
Results: mpMRI demonstrated higher sensitivity in detecting extraprostatic extension (EPE) and bladder neck invasion (BNI) compared to Ga-68 PSMA PET/CT (83% vs. 44% and 29% vs. 17%, respectively). Conversely, Ga-68 PSMA PET/CT showed higher sensitivity in detecting seminal vesicle invasion (SVI) and lymph node metastasis (LNM) (75% vs. 55% and 50% vs. 30%, respectively). When both methods were combined, sensitivity increased in detecting both EPE and SVI. The index tumor localization in mpMRI and Ga-68 PSMA PET/CT was found to be in complete agreement with histopathological findings at 36.4% and 41.8%, respectively. When both imaging methods were combined, the agreement with histopathology in predicting index tumor localization reached 72.1%.
Conclusion: Both mpMRI and Ga-68 PSMA PET/CT provide valuable and complementary information for tumor localization and locoregional staging. While mpMRI showed higher sensitivity in detecting EPE, Ga-68 PSMA PET/CT demonstrated superior performance in detecting LNM and SVI. The combined use of these imaging modalities enhance accuracy of index tumor localizations.
(© 2024 The Author(s). The Prostate published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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