Supramolecular Architectures of Dendritic Polymers Provide Irreversible Inhibitor to Block Viral Infection.

Autor: Mohammadifar E; Institut für Chemie und Biochemie Freie Universität Berlin, Takustr 3, 14195, Berlin, Germany., Gasbarri M; Institute of Materials, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland., Dimde M; Forschungszentrum für Elektronenmikroskopie und Gerätezentrum BioSupraMol, Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, Germany., Nie C; Institut für Chemie und Biochemie Freie Universität Berlin, Takustr 3, 14195, Berlin, Germany., Wang H; Institute of Materials, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland., Povolotsky TL; Institut für Chemie und Biochemie Freie Universität Berlin, Takustr 3, 14195, Berlin, Germany., Kerkhoff Y; Forschungszentrum für Elektronenmikroskopie und Gerätezentrum BioSupraMol, Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, Germany., Desmecht D; Animal Pathology, FARAH Research Center, Faculty of Veterinary Medicine, University of Liège, Sart-Tilman B43, Liège, 4000, Belgium., Prevost S; Institut Laue-Langevin - The European Neutron Source, 71 avenue des Martyrs - CS 20156 38042, Grenoble, cedex 9, France., Zemb T; ICSM, CEA, CNRS, ENSCM, Univ Montpellier, Bagnols-sur-Ceze, 30207, France., Ludwig K; Forschungszentrum für Elektronenmikroskopie und Gerätezentrum BioSupraMol, Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, Germany., Stellacci F; Institute of Materials, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland., Haag R; Institut für Chemie und Biochemie Freie Universität Berlin, Takustr 3, 14195, Berlin, Germany.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Sep 30, pp. e2408294. Date of Electronic Publication: 2024 Sep 30.
DOI: 10.1002/adma.202408294
Abstrakt: In Nature, most known objects can perform their functions only when in supramolecular self-assembled from, e.g. protein complexes and cell membranes. Here, a dendritic polymer is presented that inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with an irreversible (virucidal) mechanism only when self-assembled into a Two-dimmensional supramolecular polymer (2D-SupraPol). Monomeric analogs of the dendritic polymer can only inhibit SARS-CoV-2 reversibly, thus allowing for the virus to regain infectivity after dilution. Upon assembly, 2D-SupraPol shows a remarkable half-inhibitory concentration (IC 50 30 nM) in vitro and in vivo in a Syrian Hamster model has a good efficacy. Using cryo-TEM, it is shown that the 2D-SupraPol has a controllable lateral size that can be tuned by adjusting the pH and use small angle X-ray and neutron scattering to unveil the architecture of the supramolecular assembly. This functional 2D-SupraPol, and its supramolecular architecture are proposed, as a prophylaxis nasal spray to inhibit the virus interaction with the respiratory tract.
(© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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