Identification and detection of conserved G-quadruplex in monkeypox virus using conformation specific fluorogenic probe.

Autor:	Pratihar S; Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, P.O., Bengaluru, 560064 Karnataka, India. tgraju@jncasr.ac.in., Venkatesh R; Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, P.O., Bengaluru, 560064 Karnataka, India. tgraju@jncasr.ac.in., Mattath MN; Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, P.O., Bengaluru, 560064 Karnataka, India. tgraju@jncasr.ac.in., Govindaraju T; Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, P.O., Bengaluru, 560064 Karnataka, India. tgraju@jncasr.ac.in.
Jazyk:	angličtina
Zdroj:	Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Nov 05; Vol. 60 (89), pp. 13004-13007. Date of Electronic Publication: 2024 Nov 05.
DOI:	10.1039/d4cc03726j
Abstrakt:	Identifying distinct noncanonical structures in pathogenic genomes is crucial for developing new diagnostic tools. This study uncovers stable G-quadruplex (GQ) structures in conserved DNA sequences unique to the monkeypox virus (MPV). Furthermore, we developed a method for the detection of target GQ using a fluorogenic probe.
Databáze:	MEDLINE
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