Trimethylamine Oxidation into the Proatherogenic Trimethylamine N-Oxide Is Higher in Coronary Heart Disease Men: From the CORDIOPREV Study.

Autor:	Garcia-Fernandez H; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, Spain.; Department of Medical and Surgical Sciences, University of Cordoba, Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain., Alcala-Diaz JF; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, Spain.; Department of Medical and Surgical Sciences, University of Cordoba, Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain., Quintana-Navarro GM; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, Spain.; Department of Medical and Surgical Sciences, University of Cordoba, Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain., Lopez-Moreno J; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, Spain.; Department of Medical and Surgical Sciences, University of Cordoba, Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain., Luque-Cordoba D; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.; Department of Analytical Chemistry and Nanochemistry University Institute, University of Cordoba, Cordoba, Spain.; CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain., Ruiz-Diaz Narvaez E; Department of Clinical Nutrition and Diet Therapy, Clinics Hospital, Faculty of Medical Sciences, National University of Asuncion, San Lorenzo, Paraguay., Arenas-de Larriva AP; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, Spain.; Department of Medical and Surgical Sciences, University of Cordoba, Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain., Gutierrez-Mariscal FM; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, Spain.; Department of Medical and Surgical Sciences, University of Cordoba, Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain., Torres-Peña JD; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, Spain.; Department of Medical and Surgical Sciences, University of Cordoba, Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain., Rodriguez-Cano D; Clinical Analysis Service, Reina Sofia University Hospital, Cordoba, Spain., Luque RM; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Cordoba, Spain., Priego-Capote F; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.; Department of Analytical Chemistry and Nanochemistry University Institute, University of Cordoba, Cordoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Cordoba, Spain., Lopez-Miranda J; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, Spain.; Department of Medical and Surgical Sciences, University of Cordoba, Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. jlopezmir@uco.es., Camargo A; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, Spain.; Department of Medical and Surgical Sciences, University of Cordoba, Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. antonio.camargo@imibic.org.
Jazyk:	angličtina
Zdroj:	The world journal of men's health [World J Mens Health] 2025 Jan; Vol. 43 (1), pp. 249-258. Date of Electronic Publication: 2024 Sep 13.
DOI:	10.5534/wjmh.230366
Abstrakt:	Purpose: Cardiovascular disease (CVD) is more prevalent in men than women, but the mechanisms responsible for this are not fully understood. We aimed to evaluate differences in trimethylamine (TMA), a microbial metabolite and its oxidized form, trimethylamine N-oxide (TMAO), which is thought to promote atherosclerosis, between men and women with coronary heart disease (CHD), using as a reference a non-CVD population. Materials and Methods: This study was carried out within the framework of the CORDIOPREV study (NCT00924937; June 19, 2009), a clinical trial which included 827 men and 175 women with CHD, with a non-CVD population of 375 individuals (270 men and 105 women) as a reference group. Plasma TMA and TMAO were measured by HPLC-MS/MS. The carotid study was ultrasonically assessed bilaterally by the quantification of intima-media thickness of both common carotid arteries (IMT-CC). Results: We found higher TMAO levels and TMAO/TMA ratio in CHD men than CHD women (p=0.034 and p=0.026, respectively). No TMA sex differences were found in CHD patients. The TMA and TMAO levels and TMAO/TMA ratio were lower, and no differences between sexes were found in the non-CVD population. TMAO levels in CHD patients were consistent with higher IMT-CC and more carotid plaques (p=0.032 and p=0.037, respectively) and lower cholesterol efflux in CHD men than CHD women (p<0.001). Conclusions: Our results suggest that CHD men have augmented TMAO levels compared with CHD women, presumably as a consequence of higher rate of TMA to TMAO oxidation, which could be associated with CVD, as these sex differences are not observed in a non-CVD population. Competing Interests: The authors have nothing to disclose. (Copyright © 2025 Korean Society for Sexual Medicine and Andrology.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu PDF