Placenta as a source of autologous graft in postnatal correction of myelomeningocele.

Autor: Barbosa IM; School of Medicine, Federal University of Alfenas, Alfenas, MG, Brazil. ingrid.barbosa@sou.unifal-mg.edu.br., Rabelo ALG; School of Medicine, Federal University of Alfenas, Alfenas, MG, Brazil., Cardoso EJR; School of Medicine, Federal University of Alfenas, Alfenas, MG, Brazil., Couto DS; School of Medicine, Federal University of Alfenas, Alfenas, MG, Brazil.
Jazyk: angličtina
Zdroj: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery [Childs Nerv Syst] 2024 Sep 30. Date of Electronic Publication: 2024 Sep 30.
DOI: 10.1007/s00381-024-06635-x
Abstrakt: Objective: This integrative literature review aims to discuss the benefits and limitations of postnatal surgery to correct myelomeningocele using the placenta as an autologous graft used on the lesion; in addition, it seeks to highlight the placental properties and the benefits and indications of surgery.
Methods: For this production, the PRISMA criteria were used. PubMed was used as a database on October 19, 2023, and three searches were made, all using the words "myelomeningocele" and "surgery" varying only between "amnion," "placenta," and "chorion" as the third word. A total of 91 articles were found, and after analysis of duplicates and inclusion and exclusion criteria, only 11 articles were used in this systematic review.
Results: Properties of the amniotic membrane were observed, such as anti-inflammatory, stimulation of native tissue growth, regenerating action by the secretion of neutrophil factors, promotion of epithelialization, inhibition of fibrosis and healing, and antibacterial effect. It is observed that there are benefits in using the placenta as an autograft and there are contradictions between the periods of surgery.
Conclusion: Due to its properties that accelerate healing, the absence of the possibility of rejection, and its easy access make this choice more frequently adopted. We are confident in saying that the effectiveness of the amniotic membrane is widely reliable.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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