Conceptual rationale for the use of chemically modified nanocomposites for active influence on atherosclerosis using the greater omentum model of experimental animals.

Autor: Akhmedov S; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012 Tomsk, Russia. Electronic address: shamil@cardio-tomsk.ru., Stepanov I; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012 Tomsk, Russia., Afanasyev S; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012 Tomsk, Russia. Electronic address: tursky@cardio-tomsk.ru., Tverdokhlebov S; School of Nuclear Science and Engineering, Tomsk Polytechnic University, 634050 Tomsk, Russia. Electronic address: tverd@tpu.ru., Filimonov V; Kizhner Research Center, Tomsk Polytechnic University, Tomsk 634050, Russia. Electronic address: filimonov@tpu.ru., Kamenshchikov N; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012 Tomsk, Russia., Yermakov A; M.N. Miheev Institute of Metal Physics of Ural Branch of Russian Academy of Sciences,620108 Ekaterinburg, Russia., Xu S; University of Science and Technology of China, Laboratory of Metabolics and Cardiovascular Diseases Institute of Endocrine and Metabolic Diseases, Division of Life Sciences and Medicine, Hefei 230027, China. Electronic address: sxu1984@ustc.edu.cn., Afanasyeva N; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012 Tomsk, Russia., Kozlov B; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012 Tomsk, Russia.
Jazyk: angličtina
Zdroj: Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2024 Nov; Vol. 62, pp. 102787. Date of Electronic Publication: 2024 Sep 27.
DOI: 10.1016/j.nano.2024.102787
Abstrakt: The use of chemically modified nanocomposites for atherosclerotic plaques can open up new opportunities for studying their effect on changing the structure of the plaque itself. It was shown on the model of the greater omentum of two groups of experimental animals (rats n = 30), which were implanted with Fe@C NPs nanocomposites of 10-30 Nm size into the omentum area. Group 1 (n = 15) consisted of animals that were implanted with chemically modified Fe@C NPs nanocomposites and control group 2 (n = 15) was with non-modified Fe@C NPs nanocomposites. After 1, 2 and 3 weeks we conducted the morphological study of changes in the structure of the omentum using two dyes (Nile Blue and Sudan III), which are specific for adipose tissue. Chemically modified nanocomposites have demonstrated, in contrast to non-modified nanoparticles, to cause morphological changes in the structure of the greater omentum accompanied by the probable release of a similar antiatherogenic factor.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
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Databáze: MEDLINE
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