Racial and Geographic Differences in Endometrial Cancer Death.

Autor:	Tan JY; Department of Internal Medicine, New York Medical College at Saint Michael's Medical Center, Newark, New Jersey, USA., Yeo YH; Department of Internal Medicine/Pediatrics, Corewell Health, Royal Oak, Michigan, USA., Thong JY; Department of Internal Medicine, Saint Vincent's Medical Center, Bridgeport, Connecticut, USA., Saleh S; Medical Student, St. George's University, Saint George's, Grenada., Mbenga K; Medical Student, St. George's University, Saint George's, Grenada., Guron G; Division of Hematology/Oncology, Department of Internal Medicine, New York Medical College at Saint Michael's Medical Center, Newark, New Jersey, USA., Shaaban HS; Division of Hematology/Oncology, Department of Internal Medicine, New York Medical College at Saint Michael's Medical Center, Newark, New Jersey, USA.
Jazyk:	angličtina
Zdroj:	Oncology [Oncology] 2024 Sep 28, pp. 1-5. Date of Electronic Publication: 2024 Sep 28.
DOI:	10.1159/000541683
Abstrakt:	Introduction: In the USA, endometrial cancer incidence rose by 4.5% annually from 1999 to 2015, reaching 18 per 100,000 women, with a disproportionate impact on African American women. Despite advancements in endometrial cancer research, racial disparities in mortality rates persist. Our retrospective cohort study aimed to investigate the mortality trends and disparities among patients with endometrial cancer in the USA. Methods: Patients with endometrial cancer mortality from 1999 to 2020 were analyzed from the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER). Age-adjusted mortality rates (AAMRs) per 100,000 individuals were compared across different races and geographical regions. Results: From 1999 to 2020, endometrial cancer accounted for 90,145 deaths in the USA. Overall, the AAMRs of endometrial cancer increased significantly from 2.50 (95% CI, 2.41-2.58) in 1999 to 3.94 (95% CI, 3.85-4.04) per 100,000 individuals in 2020, with an AAPC of +2.23 (95% CI, 1.39-3.07). The highest AAMR was observed among African Americans (2.69 [95% CI, 2.65-2.74]), followed by whites (1.44 [95% CI, 1.43-1.45]), Hispanics (1.16 [95% CI, 1.13-1.20]), Asians (1.00 [95% CI, 0.96-1.04]), and American Indians (0.99 [95% CI, 0.88-1.10]). The highest AAMR from endometrial cancer was recorded in the Northeast region (1.73 [95% CI, 1.71-1.76]). Conclusion: There was an increasing trend of mortality rates from endometrial cancer in the last 2 decades, which disproportionately affected African Americans. Targeted interventions are warranted to address the mortality disparities among patients with endometrial cancer. (© 2024 S. Karger AG, Basel.)
Databáze:	MEDLINE
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