Effects of Neonatal Administration of Non-Opiate Analogues of Leu-Enkephalin on the Delayed Cardiac Consequences of Intrauterine Hypoxia.

Autor: Gusev IA; Far-East State Medical University, Ministry of Health of the Russian Federation, Khabarovsk, Russia. gusilia99@mail.ru., Malofey YB; Far-East State Medical University, Ministry of Health of the Russian Federation, Khabarovsk, Russia., Sazonova EN; Far-East State Medical University, Ministry of Health of the Russian Federation, Khabarovsk, Russia.; Khabarovsk Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration - Research Institute of Maternity and Child Protection, Khabarovsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Sep; Vol. 177 (5), pp. 610-615. Date of Electronic Publication: 2024 Sep 28.
DOI: 10.1007/s10517-024-06234-5
Abstrakt: Intrauterine hypoxia (gestation days 15-19, pO 2 65 mm Hg, duration 4 h) led to an increase in the expression of p53, beclin-1, endothelial NO synthase (eNOS), and caspase-3 proteins in cardiomyocytes and reduced the number of mast cells in the heart of 60-day-old albino rats. Administration of a non-opiate analogue of leu-enkephalin (NALE peptide: Phe-D-Ala-Gly-Phe-Leu-Arg, 100 μg/kg) on days 2-6 of the neonatal period decreased the severity of delayed posthypoxic myocardial reaction. The content of eNOS + cardiomyocytes and the total number of mast cells of these animals did not differ from the control parameters; the content of p53 + cardiomyocytes was significantly lower than in animals exposed to intrauterine hypoxia. The cardioprotective activity of NALE was partially neutralized by co-administration with the NO synthase inhibitor (L-NAME, 50 mg/kg). Correction of the delayed posthypoxic changes, similar to the effects of NALE peptide, was observed after neonatal administration of its arginine-free analogue, G peptide (Phe-D-Ala-Gly-Phe-Leu-Gly; 100 μg/kg). Non-opiate analogues of leu-enkephalin NALE and G peptides can be considered as promising substances capable of preventing long-term cardiac consequences of intrauterine hypoxia.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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