Age-Related Features of the Function of the Hypothalamic-Pituitary-Thyroid (HPT) Axis in Nonhuman Primates under Constant Lighting.

Autor: Goncharova ND; Laboratory of Experimental Endocrinology, Kurchatov Complex of Medical Primatology, National Research Centre 'Kurchatov Institute', Sochi, Russia. ndgoncharova@mail.ru., Ermolaeva AM; Laboratory of Experimental Endocrinology, Kurchatov Complex of Medical Primatology, National Research Centre 'Kurchatov Institute', Sochi, Russia., Chigarova OA; Laboratory of Experimental Endocrinology, Kurchatov Complex of Medical Primatology, National Research Centre 'Kurchatov Institute', Sochi, Russia., Oganyan TE; Laboratory of Experimental Endocrinology, Kurchatov Complex of Medical Primatology, National Research Centre 'Kurchatov Institute', Sochi, Russia., Timoshenko NV; Laboratory of Experimental Endocrinology, Kurchatov Complex of Medical Primatology, National Research Centre 'Kurchatov Institute', Sochi, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Sep; Vol. 177 (5), pp. 592-597. Date of Electronic Publication: 2024 Sep 28.
DOI: 10.1007/s10517-024-06230-9
Abstrakt: We studied the features of the functioning of the hypothalamic-pituitary-thyroid (HPT) axis under conditions of constant (4 weeks) lighting (LED lamps intended for office and residential premise) on a translational model of young adult and old female rhesus monkeys, in particular taking into account their behavior. Constant lightning had no significant effect on the levels of thyroid-stimulating hormone, thyroxine, and triiodothyronine under basal conditions in all animals, regardless of age and behavioral characteristics, but induced a decrease in thyroid function under conditions of its activation with thyrotropin-releasing hormone, mainly in old animals.
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Databáze: MEDLINE
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