Study on novel neutron irradiation without beam shaping assembly in Boron Neutron Capture Therapy.

Autor: Verdera A; Department of Atomic, Molecular and Nuclear Physics, Universidad de Granada, 18072, Granada, Spain., Praena J; Department of Atomic, Molecular and Nuclear Physics, Universidad de Granada, 18072, Granada, Spain. jpraena@ugr.es.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Sep 28; Vol. 14 (1), pp. 22434. Date of Electronic Publication: 2024 Sep 28.
DOI: 10.1038/s41598-024-73458-w
Abstrakt: Boron Neutron Capture Therapy (BNCT) is performed using high-intensity neutron sources; however, the energy of the primary neutrons is too high for direct patient irradiation. Thus, neutron moderation is mandatory and is performed using a device known as a Beam Shaping Assembly (BSA). Due to the differences in flux and energy spectra between neutron sources, each facility needs a dedicated BSA design, whether it is based on a nuclear reactor or, more recently, on an accelerator. Since moderation involves the loss of neutrons, typically by a factor of 1000, it is necessary to generate a very high flux before neutrons pass through the BSA. We propose a novel approach that eliminates the necessity of a BSA, BSA-free, by generating neutrons suitable in flux and energy for direct patient irradiation through the [Formula: see text]Sc(p,n)[Formula: see text]Ti reaction using near-threshold protons. Our findings demonstrate that all IAEA quality factors for BNCT can be met with existing proton accelerators. Additionally, figures of merit studied provide similar results compared to real BNCT facilities. This breakthrough opens up new avenues in BNCT, among others, the control of the neutron penetration within the human body by small changing in the proton energy. Also, it is expected simplified accelerator-based facilities in terms of manufacturing and maintenance and operation. This work is a study based on experimental data and Monte Carlo simulations. Technical challenges and safety are addressed in Discussion section. This novel proposal is under evaluation as patent.
(© 2024. The Author(s).)
Databáze: MEDLINE
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