Non-alcoholic fatty liver disease: A new predictor of recurrent ischemic stroke and transient ischemic attack in patients with carotid atherosclerosis.

Autor: Xu T; Cheeloo College of Medicine, Shandong University, No. 44, Wenhua West Road, Jinan 250012, Shandong, China; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, No. 324, Jingwu Road, Jinan 250021, Shandong, China., Li S; Cheeloo College of Medicine, Shandong University, No. 44, Wenhua West Road, Jinan 250012, Shandong, China; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, No. 324, Jingwu Road, Jinan 250021, Shandong, China., Wu S; Cheeloo College of Medicine, Shandong University, No. 44, Wenhua West Road, Jinan 250012, Shandong, China; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, No. 324, Jingwu Road, Jinan 250021, Shandong, China., Zhang S; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, No. 324, Jingwu Road, Jinan 250021, Shandong, China. Electronic address: z6321106@163.com., Wang X; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, No. 324, Jingwu Road, Jinan 250021, Shandong, China. Electronic address: wangxm369@sohu.com.
Jazyk: angličtina
Zdroj: European journal of radiology [Eur J Radiol] 2024 Dec; Vol. 181, pp. 111754. Date of Electronic Publication: 2024 Sep 23.
DOI: 10.1016/j.ejrad.2024.111754
Abstrakt: Purpose: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. This study focused on assessing the predictive significance of NAFLD for recurrent stroke and transient ischemic attack (TIA) risk to determine the value of NAFLD.
Method: This study included 742 participants (mean age: 64.26 ± 9.42 years, 497 males) with carotid atherosclerosis who underwent carotid CT angiography (CTA) between January 2013 and December 2021 in this retrospective study. NAFLD was diagnosed by non-enhanced abdominal CT. The clinical endpoint was a recurrent ischemic stroke or TIA. Cox proportional hazards and Kaplan-Meier analysis assessed whether NAFLD was associated with the endpoint. We accessed the predictive values of NAFLD, clinical, plaque characteristics, and combined model by the C statistics. The predictive performance of the combined model was assessed by receiver operating characteristic curve (ROC) analysis.
Results: A total of 742 participants (mean age: 64.26 ± 9.42 years, 497 males) were included. During 2.9 years of follow-up (interquartile range, 2.1-3.9), 166 patients reached the clinical endpoint. Multivariable cox analyses showed NAFLD was associated with recurrent stroke or TIA in all groups (all P<0.05). Patients with NAFLD had a lower event-free survival (EFS) rate than those without NAFLD (P<0.05). The combined model, including NAFLD, clinical data and plaque features, showed the best performance in predicting the clinical endpoint (AUC=0.79).
Conclusions: NAFLD contributes to the prediction of recurrent ischemic stroke or TIA. NAFLD may be a novel imaging marker that offers a new perspective on preventing cardiovascular disease in the clinic.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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