Physiological and pathological aspects of epididymal sperm maturation.

Autor: Weigel Muñoz M; Instituto de Biología y Medicina Experimental (IBYME). Fundación IBYME. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: m.weigel@ibyme.org.ar., Cohen DJ; Instituto de Biología y Medicina Experimental (IBYME). Fundación IBYME. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: d.cohen@ibyme.org.ar., Da Ros VG; Instituto de Biología y Medicina Experimental (IBYME). Fundación IBYME. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: v.daros@ibyme.org.ar., González SN; Instituto de Biología y Medicina Experimental (IBYME). Fundación IBYME. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: s.gonzalez@ibyme.org.ar., Rebagliati Cid A; Instituto de Biología y Medicina Experimental (IBYME). Fundación IBYME. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: a.rebagliati@ibyme.org.ar., Sulzyk V; Instituto de Biología y Medicina Experimental (IBYME). Fundación IBYME. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: v.sulzyk@ibyme.org.ar., Cuasnicu PS; Instituto de Biología y Medicina Experimental (IBYME). Fundación IBYME. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: pcuasnicu@gmail.com.
Jazyk: angličtina
Zdroj: Molecular aspects of medicine [Mol Aspects Med] 2024 Dec; Vol. 100, pp. 101321. Date of Electronic Publication: 2024 Sep 27.
DOI: 10.1016/j.mam.2024.101321
Abstrakt: In mammals, sperm that leave the testes are nonfunctional and require a complex post-testicular maturation process to acquire their ability to recognize and fertilize the egg. The crucial maturation changes that provide sperm their fertilizing capability occur while passing through the epididymis. Due to the widespread use of assisted reproductive technologies to address male infertility, there has been a significant decrease in research focusing on the mechanisms underlying the maturation process over the past decades. Considering that up to 40% of male infertility is idiopathic and could be reflecting sperm maturation defects, the study of post-testicular sperm maturation will clearly contribute to a better understanding of the causes of male infertility and to the development of both new approaches to maturing sperm in vitro and safer male contraceptive methods. Based on this, the present review focuses on the physiopathology of the epididymis as well as on current approaches under investigation to improve research in sperm maturation and as potential therapeutic options for male infertility.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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