Localized cystic disease of the kidney: study of 14 cases and review of the literature.

Autor: Tannous E; Department of Pathology and Laboratory Medicine, Albany Medical Center, 43 New Scotland Avenue, Room F110G3, Albany, NY, USA., Patel S; Department of Pathology and Laboratory Medicine, Albany Medical Center, 43 New Scotland Avenue, Room F110G3, Albany, NY, USA., Muratoglu B; Department of Pathology, Yale University, New Haven, CT, USA., Lightle AR; Department of Pathology and Laboratory Medicine, Albany Medical Center, 43 New Scotland Avenue, Room F110G3, Albany, NY, USA., Pacheco RR; Department of Pathology and Laboratory Medicine, Albany Medical Center, 43 New Scotland Avenue, Room F110G3, Albany, NY, USA., Hosseini R; Department of Pathology and Laboratory Medicine, Albany Medical Center, 43 New Scotland Avenue, Room F110G3, Albany, NY, USA., Pacheco RR; Department of Radiology, Albany Medical Center, Albany, NY, USA., Kim P; Department of Radiology, Albany Medical Center, Albany, NY, USA., Cetinkaya GT; Department of Pathology, Loyola University School of Medicine, Maywood, IL, USA., Baydar DE; Department of Pathology and Laboratory Medicine, Koc University, Istanbul, Turkey., Kosemehmetoglu K; Department of Pathology and Laboratory Medicine, Hacettepe University, Ankara, Turkey., Karabulut YY; Department of Pathology and Laboratory Medicine, Mersin University Hospital, Ankara, Turkey., Appu S; Department of Surgery, Monash University, Melbourne, Victoria, Australia., Galea LA; Department of Anatomical Pathology, Melbourne Pathology, Sonic Healthcare, Melbourne, Victoria, Australia., Bernstein AN; Department of Urology, Albany Medical Center, Albany, NY, USA., Akgul M; Department of Pathology and Laboratory Medicine, Albany Medical Center, 43 New Scotland Avenue, Room F110G3, Albany, NY, USA. akgulm@amc.edu.
Jazyk: angličtina
Zdroj: Virchows Archiv : an international journal of pathology [Virchows Arch] 2024 Sep 28. Date of Electronic Publication: 2024 Sep 28.
DOI: 10.1007/s00428-024-03930-5
Abstrakt: Localized cystic disease of the kidney (LCDK) is rare without hereditary background and does not progress. It can mimic neoplastic process, leading to unnecessary surgical intervention. We present 14 patients [male-to-female 9:5; mean age 50.3 years (range: 3-79)] with LCDK in a multinational cohort. Flank pain (n=5) and incidental lesions (n=4) were common. All cases were unilateral (9 right, 5 left), and contralateral kidneys were mostly normal (n=11). No family history was present, and none had extrarenal solid organ cysts. Radical and partial nephrectomies were performed in 9 and 5 cases, respectively. All lesions were multilocular, ranging from 1.8 - 20cm. 2 cases had diffuse renal involvement. Cystic septa contained nonneoplastic elements including renal tubules and glomeruli without primitive epithelial cellular elements, blastema, or immature stromal cells. In addition, we also comprehensively reviewed 75 previously reported cases. Conclusions. LCDK should be considered in the differential of cystic kidney lesions.
Competing Interests: Declarations. Conflict of interest: The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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