In Vivo and In Vitro Approaches to Modeling Hypoplastic Left Heart Syndrome.

Autor: Alonzo M; Center for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, 43215, USA.; The Heart Center, Nationwide Children's Hospital, Columbus, OH, 43215, USA., Contreras J; Center for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, 43215, USA.; The Heart Center, Nationwide Children's Hospital, Columbus, OH, 43215, USA., Bering J; Center for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, 43215, USA.; The Heart Center, Nationwide Children's Hospital, Columbus, OH, 43215, USA., Zhao MT; Center for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, 43215, USA. Mingtao.Zhao@NationwideChildrens.org.; The Heart Center, Nationwide Children's Hospital, Columbus, OH, 43215, USA. Mingtao.Zhao@NationwideChildrens.org.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, 43210, USA. Mingtao.Zhao@NationwideChildrens.org.; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA. Mingtao.Zhao@NationwideChildrens.org.
Jazyk: angličtina
Zdroj: Current cardiology reports [Curr Cardiol Rep] 2024 Nov; Vol. 26 (11), pp. 1221-1229. Date of Electronic Publication: 2024 Sep 28.
DOI: 10.1007/s11886-024-02122-6
Abstrakt: Purpose of Review: Hypoplastic left heart syndrome (HLHS) is a critical congenital heart defect characterized by the underdevelopment of left-sided heart structures, leading to significant circulatory challenges, and necessitating multiple surgeries for survival. Despite advancements in surgical interventions, long-term outcomes often involve heart failure, highlighting the need for a deeper understanding of HLHS pathogenesis. Current in vivo and in vitro models aim to recapitulate HLHS anatomy and physiology, yet they face limitations in accuracy and complexity.
Recent Findings: In vivo models, including those in chick, lamb, and mouse, provide insights into hemodynamic and genetic factors influencing HLHS. In vitro models using human induced pluripotent stem cells offer valuable platforms for studying genetic mutations and cellular mechanisms. This review evaluates these models' utility and limitations, and proposes future directions for developing more sophisticated models to enhance our understanding and treatment of HLHS.
(© 2024. The Author(s).)
Databáze: MEDLINE
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