Investigation of the Effects of Boric Acid against Post Operative Testicular Adhesion Caused by Experimental Laporotomy in Rats.

Autor: Bolat İ; Department of Pathology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey. ismail.bolat@atauni.edu.tr., Bolat M; Department of Physiology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey., Kiliçlioğlu M; Department of Pathology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey., Okur S; Department of Surgery, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey., Gölgeli A; Department of Surgery, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey., Gözegir B; Department of Pathology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey., Çomakli S; Department of Pathology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey., Yildirim S; Department of Pathology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey., Sağlam YS; Department of Pathology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey., Warda M; Department of Physiology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey.; Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2024 Sep 28. Date of Electronic Publication: 2024 Sep 28.
DOI: 10.1007/s12011-024-04400-4
Abstrakt: Post-operative intra-abdominal adhesions, significantly affecting testicular tissue, are a prevalent and serious complication following laparoscopic surgery. This study investigated the efficacy of boric acid, known for its antioxidant, anti-inflammatory, and anti-apoptotic properties, in preventing post-operative testicular adhesions. Forty rats, were divided into four groups: control, laparoscopy (LA), boric acid (BA), and LA + BA. Following laparoscopic surgery, BA treatment was administered for seven days. While the adhesion score was around 3 in the LA group, it was 1 or below in the LA + BA group. Testicular tissues were examined by histopathological and biochemical methods. In testis tissues, in the LA group, malondialdehyde (MDA) levels increased while superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) levels decreased; these parameters normalized with BA treatment. Additionally, the LA group exhibited reduced levels of IL-10, Bcl-2, Kisspeptin-1, and GnRH, alongside elevated levels of inflammatory markers IL-1β, IL-6, TNF-α, JNK, BAX, and Caspase 3. BA treatment significantly restored these levels to normal. In conclusion, oxidative stress, inflammation, and apoptosis in testicular tissues were associated with post-operative testicular adhesions. BA demonstrated potential as an anti-adhesive agent, reducing testicular adhesions and normalizing biochemical and histological parameters following laparoscopic surgery.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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