Development of pH-responsive Hydrogel from Copolymers of Artemisia vulgaris Seed Mucilage, Mucin, and poly(methacrylate) for Controlled Delivery of Acyclovir Sodium.

Autor: Taslim F; Faculty of Pharmacy, the University of Lahore, Lahore, 54600, Pakistan., Ashraf MU; Faculty of Pharmacy, the University of Lahore, Lahore, 54600, Pakistan., Farooq M; Faculty of Pharmacy, the University of Lahore, Lahore, 54600, Pakistan., Mahmood A; Faculty of Pharmacy, University of Chakwal, Chakwal, 48800, Pakistan., Sarfraz RM; College of Pharmacy, University of Sargodha, Sargodha, 40100, Pakistan., Ijaz H; Department of Pharmaceutical Sciences, Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology, Mang, Khanpur Road, Haripur, Khyber Pakhtunkhwa, 22620, Pakistan., Shahid N; Faculty of Pharmacy, the University of Lahore, Lahore, 54600, Pakistan., Gad HA; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.; Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, Jeddah, 21442, Saudi Arabia.
Jazyk: angličtina
Zdroj: Macromolecular rapid communications [Macromol Rapid Commun] 2024 Nov; Vol. 45 (22), pp. e2400421. Date of Electronic Publication: 2024 Sep 28.
DOI: 10.1002/marc.202400421
Abstrakt: To cope with the constraints of conventional drug delivery systems, site-specific drug delivery systems are the major focus of researchers. The present research developed water-swellable, pH-responsive methacrylic acid-based hydrogel scaffolds of Artemisia vulgaris seed mucilage with mucin and loaded with acyclovir sodium as a model drug. The developed hydrogel discs are evaluated for diverse parameters. Drug loading efficiency in all formulations ranges from 63% to 75%. The hydrogels exhibited pH-dependent swelling, displaying optimum swelling in a phosphate buffer (pH 7.4), and insignificant swelling in an acidic buffer (pH 1.2), in addition, they responded well to electrolyte concentrations. The sol-gel fraction is estimated ranging from 60 to 95%. Dissolution studies unveiled sustained drug release for 24 h in a phosphate buffer of pH 7.4, exhibiting zero-order release kinetics. Moreover, FTIR spectra confirmed the drug-excipient compatibility. SEM photomicrographs revealed a rough and porous surface of hydrogel discs with several pores and channels. The PXRD diffractograms exposed the amorphous nature of the polymeric blends. The findings of acute toxicity studies proved the developed hydrogel network is biocompatible. Therefore, these outcomes connote the newly created network as a smart delivery system, able to dispatch acyclovir sodium into the intestinal segment for a prolonged period.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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