| Autor: |
Ahlin R; Division of Clinical Cancer Epidemiology, Institute of Clinical Sciences, Department of Oncology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Cancer Rehabilitation, Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden., Josefsson A; Sahlgrenska Cancer Center, Institute of Clinical Sciences, Department of Urology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Wallenberg Center for Molecular Medicine, Umeå University, Umeå, Sweden.; Department of Diagnostics and Interventions, Urology, Umeå University, Umeå, Sweden., Nybacka S; Institute of Medicine, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Landberg R; Division of Food and Nutrition Science, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden., Stranne J; Institute of Clinical Sciences, Department of Urology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Urology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Steineck G; Division of Clinical Cancer Epidemiology, Institute of Clinical Sciences, Department of Oncology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden., Hedelin M; Division of Clinical Cancer Epidemiology, Institute of Clinical Sciences, Department of Oncology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
| Abstrakt: |
A phytoestrogen-rich diet has been suggested to reduce tumor proliferation among men with prostate cancer, and the effect may differ between men with different polymorphisms of the estrogen receptor-beta gene (ERβ). Patients with low- or intermediate-risk prostate cancer scheduled for radical prostatectomy were randomized to an intervention group ( n = 71) provided with soybeans and flaxseeds (∼200 mg phytoestrogens/day) to eat until surgery (approximately 6 wk) or to a control group ( n = 69). Tumor proliferation was assessed using Ki-67 indexes, prostate-specific antigen (PSA) concentrations were analyzed in blood, and ERβ polymorphism was genotyped in all subjects. The intervention group had a 13% unit lower risk [95% confidence interval (CI): -28%, 1.8%] of a higher Ki-67 index compared to controls, but the effect was most pronounced among TT carriers of ERβ [risk difference (RD) -19%, 95% CI: -45%, 6.8%]. Subjects with genotype TC/CC had a lower risk (RD -29%, 95% CI: -46%, -1.2%) and TT genotype a higher risk (RD 25%, 95% CI: 8.7%, 42%) of increased PSA concentration, comparing the intervention group to controls. In conclusion, a phytoestrogen-rich diet may cause lower tumor proliferation and concentration of PSA in men with prostate cancer with a specific genetic upset of ERβ. |
