Chemical Composition, Anti-microbial, and Cytotoxic activities of Essential Oils from Blumea densiflora var. hookeri (C.B. Clarke ex Hook.f.) C.C. Chang & Y.Q. Tseng Leaves from Vietnam.

Autor: Nguyen NV; Dalat University, Biology, 01 Phu Dong Thien Vuong, 67000, Dalat, VIET NAM., Hoang BT; University of DaLat, Biology, 01 Phu Dong Thien Vuong, Dalat, VIET NAM., Trinh DT; University of DaLat, Faculty of Chemistry and Environment, 01 Phu Dong Thien Vuong, Dalat, VIET NAM.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Sep 28, pp. e202401865. Date of Electronic Publication: 2024 Sep 28.
DOI: 10.1002/cbdv.202401865
Abstrakt: The essential oil from the leaves of Blumea densiflora var. hookeri was analyzed using GC-MS, and bioassays were performed. GC-MS identified thirty-four constituents, representing 98.7% of the oil composition. The major compounds identified in the oil were (E)-caryophyllene (15.3%), viridiflorol (5.5%), trans-dauca-4(11),7-diene (4.6%), spathulenol (4.4%), and isolongifolan-7-α-ol (4.3%). The antimicrobial activity of the oil was assessed to determine its efficacy against six bacterial strains and one fungal strain using minimum inhibitory concentration (MIC) methods. The essential oil demonstrated antimicrobial activity against all tested microorganisms. A cytotoxicity assay was performed on KB and A549 cancer cell lines using the MTT method. The essential oil displayed strong cytotoxic effects on both cell lines, with IC50 values of 1.40 ± 0.05 μg/mL for KB and 1.72 ± 0.04 μg/mL for A549.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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