Novel Carbohydrate Polymer-Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials.

Autor: Udaipuria N; School of Pharmacy and Technology Management, SVKM'S NMIMS Deemed-to-be University, Shirpur, India., Bhattacharya S; School of Pharmacy and Technology Management, SVKM'S NMIMS Deemed-to-be University, Shirpur, India.
Jazyk: angličtina
Zdroj: Biopolymers [Biopolymers] 2025 Jan; Vol. 116 (1), pp. e23632. Date of Electronic Publication: 2024 Sep 27.
DOI: 10.1002/bip.23632
Abstrakt: Due to their biocompatibility, biodegradability, and controlled release, carbohydrates polymers are crucial to targeted drug delivery systems, notably for colon cancer treatment. This article examines how carbohydrate polymers like chitosan, pectin, guar gum, alginate, hyaluronic acid, dextran, and chondroitin sulfate are used in improved drug delivery. Modifying these polymers improves drug loading, stability, and release patterns, enhancing chemotherapeutic drugs' therapeutic index. Chitosan nanoparticles are pH-responsive, making them perfect for cancer treatment. Pectin's resistance to gastric enzymes and colonic bacteria makes it a promising colon-specific medication delivery agent. The combination of these polymers with nanotechnology, 3D printing, and AI allows the creation of stimuli-responsive systems that release drugs precisely in response to environmental signals like pH, redox potential, or colon enzymatic activity. The review highlights intelligent delivery system design advances that reduce systemic toxicity, improve treatment efficacy, and improve patient adherence. Carbohydrate polymers will revolutionize colon cancer treatment with personalized and accurate alternatives.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: