Neurocardiology: translational advancements and potential.

Autor: Herring N; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Ajijola OA; UCLA Neurocardiology Research Center of Excellence, David Geffen School of Medicine, Los Angeles, CA, USA., Foreman RD; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Gourine AV; Centre for Cardiovascular and Metabolic Neuroscience, University College London, London, UK., Green AL; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Osborn J; Department of Surgery, University of Minnesota, Minneapolis, MN, USA., Paterson DJ; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Paton JFR; Manaaki Manawa - The Centre for Heart Research, Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Ripplinger CM; Department of Pharmacology, University of California Davis, Davis, CA, USA., Smith C; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA., Vrabec TL; Department of Physical Medicine and Rehabilitation, School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Wang HJ; Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, USA., Zucker IH; Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA., Ardell JL; UCLA Neurocardiology Research Center of Excellence, David Geffen School of Medicine, Los Angeles, CA, USA.
Jazyk: angličtina
Zdroj: The Journal of physiology [J Physiol] 2024 Sep 27. Date of Electronic Publication: 2024 Sep 27.
DOI: 10.1113/JP284740
Abstrakt: In our original white paper published in the The Journal of Physiology in 2016, we set out our knowledge of the structural and functional organization of cardiac autonomic control, how it remodels during disease, and approaches to exploit such knowledge for autonomic regulation therapy. The aim of this update is to build on this original blueprint, highlighting the significant progress which has been made in the field since and major challenges and opportunities that exist with regard to translation. Imbalances in autonomic responses, while beneficial in the short term, ultimately contribute to the evolution of cardiac pathology. As our understanding emerges of where and how to target in terms of actuators (including the heart and intracardiac nervous system (ICNS), stellate ganglia, dorsal root ganglia (DRG), vagus nerve, brainstem, and even higher centres), there is also a need to develop sensor technology to respond to appropriate biomarkers (electrophysiological, mechanical, and molecular) such that closed-loop autonomic regulation therapies can evolve. The goal is to work with endogenous control systems, rather than in opposition to them, to improve outcomes.
(© 2024 The Author(s). The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.)
Databáze: MEDLINE
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