| Autor: |
Kondrashina A; Health and Happiness (H&H) Group, H&H Research, Global Research and Technology Centre, Fermoy, P61 K202 Co. Cork, Ireland., Mamone G; Institute of Food Science, National Research Council, 83100 Avellino, Italy., Giblin L; Teagasc Food Research Centre, Moorepark, Fermoy, P61 P302 Co. Cork, Ireland., Lane JA; Health and Happiness (H&H) Group, H&H Research, Global Research and Technology Centre, Fermoy, P61 K202 Co. Cork, Ireland. |
| Abstrakt: |
Human breast milk (HBM) is the "gold standard" for infant nutrition. When breast milk is insufficient or unavailable, infant milk formula (IMF) can provide a safe and nutritious alternative. However, IMFs differ considerably from HBM in composition and health function. We compared the digestibility and potential health functions of IMF containing low cream (LC-) or high cream (HC-) with pooled HBM. After simulated infant digestion of these samples, the bioavailability of key nutrients and immunomodulatory activities were determined via cell-based in vitro assays. A Caenorhabditis elegans leaky gut model was established to investigate cream effects on gut health. Distinct differences were observed in peptide diversity and sequences released from HC-IMF compared with LC-IMF during simulated digestion ( p < 0.05). Higher levels of free fatty acids were absorbed through 21-day differentiated Caco-2/HT-29MTX monolayers from HC-IMF, compared with LC-IMF and HBM ( p < 0.05). Furthermore, the immune-modulating properties of HC-IMF appeared to be more similar to HBM than LC-IMF, as observed by comparable secretion of cytokines IL-10 and IL-1β from THP-1 macrophages ( p > 0.05). HC-IMF also supported intestinal recovery in C. elegans following distortion versus LC-IMF ( p < 0.05). These observations suggest that cream as a lipid source in IMF may provide added nutritional and functional benefits more aligned with HBM. |
