| Autor: |
Hangan AC; Department of Inorganic Chemistry, Faculty of Pharmacy, 'Iuliu-Hațieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania., Oprean LS; Department of Inorganic Chemistry, Faculty of Pharmacy, 'Iuliu-Hațieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania., Dican L; Department of Medical Biochemistry, Faculty of Medicine, 'Iuliu-Hațieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania., Procopciuc LM; Department of Medical Biochemistry, Faculty of Medicine, 'Iuliu-Hațieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania., Sevastre B; Clinic Department, Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 400372 Cluj-Napoca, Romania., Lucaciu RL; Department of Pharmaceutical Biochemistry and Clinical Laboratory, Faculty of Pharmacy, 'Iuliu-Hațieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. |
| Abstrakt: |
DNA structure has many potential places where endogenous compounds and xenobiotics can bind. Therefore, xenobiotics bind along the sites of the nucleic acid with the aim of changing its structure, its genetic message, and, implicitly, its functions. Currently, there are several mechanisms known to be involved in DNA binding. These mechanisms are covalent and non-covalent interactions. The covalent interaction or metal base coordination is an irreversible binding and it is represented by an intra-/interstrand cross-link. The non-covalent interaction is generally a reversible binding and it is represented by intercalation between DNA base pairs, insertion, major and/or minor groove binding, and electrostatic interactions with the sugar phosphate DNA backbone. In the present review, we focus on the types of DNA-metal complex interactions (including some representative examples) and on presenting the methods currently used to study them. |
