Visceral Fat Thickness, Serum Adiponectin, and Metabolic Syndrome in Patients with Colorectal Adenomas.

Autor:	Damjanov D; Faculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia.; Clinic for Gastroenterology and Hepatology, University Clinical Center of Vojvodina, 21137 Novi Sad, Serbia., Ičin T; Faculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia.; Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Vojvodina, 21137 Novi Sad, Serbia., Savić Ž; Faculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia.; Clinic for Gastroenterology and Hepatology, University Clinical Center of Vojvodina, 21137 Novi Sad, Serbia., Janjić N; Faculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia.; Clinic for Gastroenterology and Hepatology, University Clinical Center of Vojvodina, 21137 Novi Sad, Serbia., Nikolić S; Faculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia.; Center for Laboratory Medicine, University Clinical Center of Vojvodina, 21137 Novi Sad, Serbia., Bošnjak OL; Clinic for Gastroenterology and Hepatology, University Clinical Center of Vojvodina, 21137 Novi Sad, Serbia., Krnetić Ž; Clinic for Gastroenterology and Hepatology, University Clinical Center of Vojvodina, 21137 Novi Sad, Serbia., Vračarić V; Clinic for Gastroenterology and Hepatology, University Clinical Center of Vojvodina, 21137 Novi Sad, Serbia., Dejanović B; Faculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia.; Clinic for Gastroenterology and Hepatology, University Clinical Center of Vojvodina, 21137 Novi Sad, Serbia., Kovačević N; Faculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia.; Clinic for Infectious Diseases, University Clinical Center of Vojvodina, 21137 Novi Sad, Serbia.
Jazyk:	angličtina
Zdroj:	Journal of personalized medicine [J Pers Med] 2024 Sep 22; Vol. 14 (9). Date of Electronic Publication: 2024 Sep 22.
DOI:	10.3390/jpm14091008
Abstrakt:	Background/objectives: Most cases of colorectal cancer (CRC) arise from adenomatous polyps. Identifying risk factors for colorectal adenoma (CRA) is critical for CRC prevention. Emerging evidence suggests a link between metabolic syndrome (MetS) and an elevated risk of CRA and CRC, potentially mediated by visceral obesity and adiponectin (APN). We aimed to evaluate the association between different markers of visceral obesity, serum APN, MetS, and the presence of CRA. Methods: A cross-sectional study was conducted at the University Clinical Center of Vojvodina, involving 120 patients, aged 40-75 years, who underwent colonoscopy between January 2022 and January 2023. Sixty patients with CRA were compared to 60 controls with normal colonoscopy findings. Visceral fat thickness (VFT) was measured using ultrasound (US), and bioelectrical impedance analysis (BIA) was used to assess visceral fat area (VFA). Serum APN levels, anthropometric measures, and MetS components were also evaluated. Results: Patients with CRA had significantly higher VFT measured by US (p < 0.05), but no significant differences were found in VFA measured by BIA, waist circumference (WC), or waist-to-hip ratio (WHR). MetS was significantly more prevalent in the CRA group (55% vs. 31.6%, p < 0.05), and logistic regression confirmed MetS as a significant predictor of CRA presence (OR = 2.6). Serum APN levels were inversely correlated with visceral fat measurements and MetS (p < 0.01), but no significant difference in APN levels was observed between patients with and without CRA. Conclusions: This study highlights the importance of VFT measured by US and the presence of MetS as significant factors associated with CRA.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu