| Autor: |
Marchlewska K; Division of Reproductive Endocrinology, Department of Andrology & Reproductive Endocrinology, Medical University of Lodz, Lodz 91-419, Poland., Erkiert-Kusiak M; 1st Department of Anesthesiology & Intensive Care, Medical University of Warsaw, Warsaw 02-005, Poland., Walczak-Jędrzejowska R; Division of Reproductive Endocrinology, Department of Andrology & Reproductive Endocrinology, Medical University of Lodz, Lodz 91-419, Poland., Słowikowska-Hilczer J; Division of Reproductive Endocrinology, Department of Andrology & Reproductive Endocrinology, Medical University of Lodz, Lodz 91-419, Poland. |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of molecular sciences [Int J Mol Sci] 2024 Sep 17; Vol. 25 (18). Date of Electronic Publication: 2024 Sep 17. |
| DOI: |
10.3390/ijms25189995 |
| Abstrakt: |
Mature, vital, and motile spermatozoa are essential for reaching the oocyte and binding to hyaluronic acid (HA) in the cumulus oophorus matrix. This study aims to determine the relationship between sperm-migration ability and HA-binding potential, as well as the relationship between sperm concentration and motility. Semen samples were collected from 702 men aged 20-56 years (median 34.8). We evaluated the sperm concentration and motility from basic semen analysis, the swim-up test (expressed as millions per mL and the migration efficiency percentage), and the hyaluronan-binding assay (HBA). A moderate positive correlation was found between the migration test results and HBA (R = 0.48). The highest correlation was observed between the concentration of motile spermatozoa and the migration test results (R = 0.85) and HBA (R = 0.4). The sperm migration efficiency strongly correlated with progressive motility (R = 0.6). Although significantly higher sperm migration was observed in patients with normal HBA results, the results of the functional tests were found to differ in some cases. For infertility treatment, the current diagnostic algorithm should be enhanced with more comprehensive seminological methods that assess the sperm-migration ability and HA-binding potential. We also recommend incorporating the swim-up method into the diagnostic protocol before planning assisted reproductive technology (ART) treatment. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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