Clinical and Immunological Factors Associated with the Progression of Lupus Nephritis in a Population from the Colombian Caribbean.

Autor:	Vélez-Verbel M; Centro de Investigaciones en Ciencias de la Vida, Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080001, Colombia., Aroca-Martínez G; Centro de Investigaciones en Ciencias de la Vida, Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080001, Colombia.; Departamento de Nefrología, Clínica de la Costa, Barranquilla 080001, Colombia., Vélez-Verbel D; Departamento de Medicina Interna, Clínica del Río, Magangué 132520, Colombia., Domínguez-Vargas A; División Ciencias de la Salud, Universidad del Norte, Barranquilla 080001, Colombia.; Data Analysis and Mining Department, D&P Consulting Service SAS, Barranquilla 080001, Colombia., Vallejo-Patiño M; Centro de Investigaciones en Ciencias de la Vida, Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080001, Colombia., Sarmiento-Gutierrez J; Centro de Investigaciones en Ciencias de la Vida, Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080001, Colombia.; Departamento de Nefrología, Clínica de la Costa, Barranquilla 080001, Colombia., Gomez-Escorcia L; Departamento de Nefrología, Clínica de la Costa, Barranquilla 080001, Colombia., Musso CG; Centro de Investigaciones en Ciencias de la Vida, Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080001, Colombia.; Nephrology Department, Hospital Italiano de Buenos Aires, Buenos Aires C1000, Argentina., González-Torres HJ; Centro de Investigaciones en Ciencias de la Vida, Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080001, Colombia.; Data Analysis and Mining Department, D&P Consulting Service SAS, Barranquilla 080001, Colombia.; Doctorado en Ciencias Biomédicas, Universidad del Valle, Cali 760001, Colombia.
Jazyk:	angličtina
Zdroj:	Biomedicines [Biomedicines] 2024 Sep 09; Vol. 12 (9). Date of Electronic Publication: 2024 Sep 09.
DOI:	10.3390/biomedicines12092047
Abstrakt:	Lupus nephritis represents a significant immune-mediated glomerulonephritis, constituting the most important organ involvement induced by systemic lupus erythematosus (SLE), with variable epidemiology and clinical presentation among populations. Objective: to identify clinical and immunological factors associated with the progression of lupus nephritis in a population from the Colombian Caribbean. Methods: we evaluated 401 patients diagnosed with SLE and lupus nephritis, treated at a reference center in the Colombian Caribbean, gathering data recorded in medical records. Results: A proportion of 87% were female, with a median age of 42 years. Most patients presented with proliferative classes (90%), with class IV being the most common (70%). A proportion of 52% of patients did not respond to treatment, which is described as the lack of complete or partial response, while 28% had a complete response. A significant decrease in hemoglobin, glomerular filtration rate, and proteinuria was identified by the third follow-up ( p < 0.001), along with an increase in creatinine, urea, and hematuria ( p < 0.001). Patients with initial proteinuria > 2 g/day were found to be 27 times more likely to be non-responders ( p < 0.001). Mortality was associated with the presence of serum creatinine >1.5 mg/dL ( p = 0.01) (OR: 1.61 CI 95% 0.75-3.75) and thrombocytopenia ( p = 0.01) (OR: 0.36; CI 95% 0.12-0.81). Conclusions: identifying factors of progression, non-response, and mortality provides an opportunity for more targeted and personalized intervention, thereby improving care and outcomes for patients with lupus nephritis.
Databáze:	MEDLINE
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